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Ornidazole Loaded Microparticulate System for Colon Targeting for Better Control of Amoebiasis: Formulation and In Vitro Characterization.
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| Author:
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UPLOADED BY-ADMIN, NARENDRA K. PATREY, SHAILENDRA WASNIK, POONAM PARMAR, ALKA ANAND
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| Abstract:
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The aim of this work is to design a new colon targeted delivery system of ornidazole by incorporating it into chitosan
microparticulates. The microparticulates were prepared by ionic gelation method, where drug containing chitosan dispersion
in 2% (v/v) acetic acid is added drop wise into the sufficient volume of sodium tripoly phosphate solution with distilled water
with the aid of 22 gauge push pull needle-syringe. The formulations were optimized for different concentration of drug
and polymer. Prepared microparticulates were evaluated for their particle size, surface morphology with SEM, drug entrapment,
percentage yield, possible drug interaction and drug release in SIF. To provide protection to formulation in the stomach
from acidic environment enteric coated system was designed. Hard gelatin capsules were firstly treated with formalin
vapour. Afterwards it was filled with the required quantity of microparticulates and were dip coated with Eudragit L&S 100
using PEG- 400 (3%w/v) as plasticizer. EudragitL&S-100 coating solution of different ratio 4:1, 3:2, 1:1, 2:3, 1:4, 1:5 were
prepared using 3% w/v PEG-400 as plasticizer in acetone : IPA (1:1). These coated capsules were tested in SGF pH 1.2, SIF
pH 6.4 and SIF pH 7.4. Application of a thicker coat causes a delay in drug release in the small intestine and slow down the
drug release, which is both pH and time controlled. This time controlled drug release may be retarded by 3-4 h. This ensures
drug delivery to be colon specific.
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| Keyword:
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Ornidazole, Eudragit, Microparticles, Colon Targeting, formalin, plasticizer.
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| DOI:
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