|
Role of NMDA receptor antagonist in ethanol withdrawal syndrome
|
|
| Author:
|
BABITA DODKE, ANKIT S. KEDIYA
|
| Abstract:
|
Abstract
The drug which is use in study along with N-Methyl D-Aspartate (NMDA) receptor antagonist is also dopamine agonist which gives the synergistic effect for the minimizing ethanol dependence. The protocol was designed to evaluate the effect of NMDA receptor antagonist on ethanol withdrawal after induction of dependence in rats. The experimental animals (control and test) were group into six (6 rats in per group) and treated by following protocol for ethanol dependence. Acute and chronic drug treatment was given to test group animal. After withdrawal of ethanol consumption by experimental animal (control and drug treated group) were observed for withdrawal symptoms somatic signs (grooming, head shake, genital licking, chewing) and anxiety. Chronic drug administration simultaneously with alcohol (development phase) counteracted alcohol withdrawal somatic signs, anxiety. However, administration of acute (single dose) after termination of alcohol treatment failed to attenuate alcohol withdrawal somatic signs, anxiety. Drug was effective to attenuate withdrawal signs; syndrome after chronic and sub chronic treatment. The somatic behaviors for each observation was calculated and expressed as mean± S.E.M.
|
| Keyword:
|
Keywords Ethanol withdrawal NMDA Dependence Anxiety Somatic sings Amantadine
|
| EOI:
|
-
|
| DOI:
|
-
|
| Download:
|
Request For Article
|
|
|