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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Role of NMDA receptor antagonist in ethanol withdrawal syndrome

Author: BABITA DODKE, ANKIT S. KEDIYA
Abstract: Abstract The drug which is use in study along with N-Methyl D-Aspartate (NMDA) receptor antagonist is also dopamine agonist which gives the synergistic effect for the minimizing ethanol dependence. The protocol was designed to evaluate the effect of NMDA receptor antagonist on ethanol withdrawal after induction of dependence in rats. The experimental animals (control and test) were group into six (6 rats in per group) and treated by following protocol for ethanol dependence. Acute and chronic drug treatment was given to test group animal. After withdrawal of ethanol consumption by experimental animal (control and drug treated group) were observed for withdrawal symptoms somatic signs (grooming, head shake, genital licking, chewing) and anxiety. Chronic drug administration simultaneously with alcohol (development phase) counteracted alcohol withdrawal somatic signs, anxiety. However, administration of acute (single dose) after termination of alcohol treatment failed to attenuate alcohol withdrawal somatic signs, anxiety. Drug was effective to attenuate withdrawal signs; syndrome after chronic and sub chronic treatment. The somatic behaviors for each observation was calculated and expressed as mean± S.E.M.
Keyword: Keywords Ethanol withdrawal NMDA Dependence Anxiety Somatic sings Amantadine
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0.07
2017CiteScore
 
11th percentile
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477