IJPR  artciles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 1.55 (2012 - 2016). 

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

Current Issue
22nd NATIONAL CONVENTION

22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit


For More Detail Visit ncsp.ganpatuniversity.ac.in
Article In Press
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPRT ISSUE

January - March 6 [1] 2014

Click to download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
PIPPHARMACON & IJPR 2018

PIPPHARMACON & IJPR 2018

Click to download
 

Article Detail

Label
Label
5-fluorouracil release from sunflower pectin hydrogels in simulated intestinal medium and its corresponding anti-carcinogenic activity

Author: IBRAHIM GÜLSEREN, BILAL ?AKIR
Abstract: 5-fluorouacil (5-FU) is a commonly used medication in the treatment of cancers including colon, stomach, pancreatic and breast cancers. In this study, 5-FU was encapsulated in low methoxyl sunflower pectin (i.e., sunflower LMP) hydrogel beads in order to investigate the potential of sunflower pectin in the delivery of cancer drugs. Calcium pectate beads were prepared using an extrusion dripping method. Dissolution kinetics were monitored in simulated intestinal fluid (SIF) medium and the dissolved fractions were analyzed for 5-FU content (RP-HPLC). These fractions were also administered to HCT 116 cell culture in order to investigate their anti-carcinogenic characteristics. The release of 5-FU was 98.5% complete after 30 min of dissolution in SIF. Increasing 5-FU concentrations in dissolved fractions inhibited HCT 116 viability significantly. After complete dissolution, cellular viability was approx. 2%. These results demonstrated that sunflower pectin might be utilized as a rapid release agent in drug delivery applications.
Keyword: Sunflower pectin; hydrogel; 5-fluorouacil (5-FU); HCT 116; anti-carcinogenic activity.
Download: Request For Article
 












USER LOGIN


Username
Password
Login | Register
AICTE INTERNATIONAL CONFERENCE

AICTE Sponsored International Conference on Challenges, Opportunities and Newer Directions of Pharmacovigilance and Clinical Research in India

Download Brochure


For More Detail Visit www.pippharmacon.org
News & Events

CiteScore 2016 -  0.09

SJR 2016 - 0.111

SNIP 2016 - 0.055

Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)