Impact Factor for Five Years is 1.55 (2012 - 2016). IJPRT Re-launched from 2017, for more details visit www.ijprtonline.com

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

Current Issue
Article In Press
ENZYMATIC AND NON ENZYMATIC ANTIOXIDANT ACTIVITY OF LEAF EXTRACTS OF AEGLE MARMELOS L. AND CENTELLA ASIATICA L.
ECO-FRIENDLY SYNTHESIS OF SILVER NANOPARTICLES USING AQUEOUS LEAVES EXTRACT OF CLOME GYNANDRA AND THEIR ANTIBACTERIAL ACTIVITY”
Synthesis, characterization, augmentation of iron oxide nanoparticles from Musa paradisaca peel extract and its antibacterial activity
Antianaphylactic Activity Polyherbal Formulation Against Systemic, Cutaneous And Compound 48/80 Induced Invitro Anaphylaxis
A study on an autoimmune disease-PSORIASIS
EFFICACY OF EMBLICA OFFICINALIS ON SERUM ENZYMES AGAINST AIR POLLUTANTS EXPOSED ALBINO RATS.
Formulation and Evaluation of Buccal Drug Delivery System of Ketorolac Tromethamine Using Mucoadhesive Polymers
Signaling pathways associated with liver cancer stem cell therapy
PHARMACOLOGICAL ACTIVITIES OF ASTAXANTHIN
A review on ethnobotany, phytochemistry and pharmacology of Plantago major L. – nature's treasure
12
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IJPRT ISSUE

January - March 6 [1] 2014

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Article Detail

Label
5-fluorouracil release from sunflower pectin hydrogels in simulated intestinal medium and its corresponding anti-carcinogenic activity

Author: IBRAHIM GÜLSEREN, BILAL ?AKIR
Abstract: 5-fluorouacil (5-FU) is a commonly used medication in the treatment of cancers including colon, stomach, pancreatic and breast cancers. In this study, 5-FU was encapsulated in low methoxyl sunflower pectin (i.e., sunflower LMP) hydrogel beads in order to investigate the potential of sunflower pectin in the delivery of cancer drugs. Calcium pectate beads were prepared using an extrusion dripping method. Dissolution kinetics were monitored in simulated intestinal fluid (SIF) medium and the dissolved fractions were analyzed for 5-FU content (RP-HPLC). These fractions were also administered to HCT 116 cell culture in order to investigate their anti-carcinogenic characteristics. The release of 5-FU was 98.5% complete after 30 min of dissolution in SIF. Increasing 5-FU concentrations in dissolved fractions inhibited HCT 116 viability significantly. After complete dissolution, cellular viability was approx. 2%. These results demonstrated that sunflower pectin might be utilized as a rapid release agent in drug delivery applications.
Keyword: Sunflower pectin; hydrogel; 5-fluorouacil (5-FU); HCT 116; anti-carcinogenic activity.
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INDEXED
Chemical Abstract Services
Scopus (Elsevier)
Embase(Elsevier)
Ulrich's International Periodical Dictionary
Indian Science Abstract
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News & Events
Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)