Impact Factor for Five Years is 1.55 (2012 - 2016). 22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in/index.php

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

Current Issue
Article In Press
Antioxidant activity and total phenolic content in 15 commonly used cucurbits in Tarai region of Kumaun, Uttarakhand.
Analytical Method Development and Validation for the Simultaneous Estimation of Ambroxol Hydrochloride and Guaiphenesin in Syrup Dosage form by RP-HPLC
Role of NMDA receptor antagonist in ethanol withdrawal syndrome
STABILITY INDICATING LC-MS/MS METHOD FOR QUANTIFICATION OF IBRUTINIB IN HUMAN PLASMA
A review on drug: Amantadine
Chemopreventive and antioxidative activity of Carissa carandas extract against chemical induced skin tumorigenesis in mice
ROLE OF AMIODARONE IN ACUTE MYOCARDIAL INFARACTION INDUCED VENTRICULAR TACHYCARDIA IN PATIENTS WITH LEFT ANTERIOR DESCENDING ARTERY INVOLVEMENT
Extraction optimisation, fractionation, standardisation, in vitro antioxidant and anticholinesterase activity of fractions of Indian Propolis
Development of validated stability-indicating analytical method for simultaneous estimation of Atenolol and Hydrochlorothiazide in pharmaceutical combined dosage form by High Performance Thin Layer Chromatography.
Lung Cancer in Lifelong Never Smokers-Short Review
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IJPRT ISSUE

January - March 6 [1] 2014

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Analytical Method Development and Validation for the Simultaneous Estimation of Ambroxol Hydrochloride and Guaiphenesin in Syrup Dosage form by RP-HPLC

Author: AZHAR KHAN, VANDANA JAIN, OJASWI GHADGE, SUDHA RATHOD
Abstract: A simple, rapid, accurate and precise reverse phase-high performance liquid chromatographic (RP-HPLC) method has been developed and validated for the simultaneous determination of Ambroxol hydrochloride and Guaiphenesin in combined dosage form. Separation was performed using Phenomex C18 column (250*4.5 mm, 0.5 µ) on LC-20 AD Prominence Liquid chromatograph (Shimadzu, Japan) attached with Spd-20A/20AV Prominence SPD-20A prominence UV/Vis detector, by using mobile phase0.02 M Potassium dihydrogen orthophosphate (pH 3.5) and Acetonitrile (30:70 V/V) isocratic elution using a flow rate of 1mL/min. Good sensitivity was observed with UV detection at 215 nm. Retention times of Ambroxol hydrochloride and Guaiphenesin were found to be about 2.39 and 2.90 min, respectively. The method was validated over the range from 3-18µg/mL for Ambroxol hydrochloride and 20-120 µg/mL for Guaiphenesin with correlation coefficients of 0.996 and 0.997, respectively. This method was shown to be accurate, specific, robust, linear, and repeatable and can be successfully employed in routine quality control for the simultaneous analysis of Ambroxol hydrochlorideand Guaiphenesin in syrup.
Keyword: Ambroxol hydrochloride, Guaiphenesin, RP-HPLC, Syrup dosage form.
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News & Events
22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in
Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)