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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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RP-HPLC Method for the Estimation of Zopiclone in Tablet Dosage Form.

Author: UPLOADED BY-ADMIN, LAKSHMANA RAO, C.RAMBABU, CH. RAJYA LAKSHMI
Abstract: A simple, rapid, sensitive and precise HPLC method has been developed for the estimation of zopiclone in pure and tablet dosage form. In this method RP-C18 column (100mmx4.6mm I.D., 3µm particle size) with mobile phase consisting of 0.02M phosphate buffer and acetonitrile in the ratio of 55:45v/v in a isocratic mode was used. The detection wavelength is 304nm and the flow rate is 1ml/min. The linearity found in the range of 20-100µg/ml and shows a correlation coefficent of 0.9913. The proposed method was validated by determining sensitivity, linearity, accuracy and precision. This method is simple, fast, accurate, precise and reproducible hence can be applied for the routine quality control analysis of zopiclone in pure and pharmaceutical dosage form.
Keyword: RP-HPLC, Zopiclone, Estimation, Validation.
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0.12
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