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Signaling pathways associated with liver cancer stem cell therapy
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| Author:
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SHILU MATHEW
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| Abstract:
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Liver cancer is a chronic disease with a poor outcome. Several progenitor markers/ hepatic stem are beneficial for isolating a subset of liver cells with stem cell features, called as cancer stem cells (CSCs). These cells are responsible for metastasis, tumor relapse, and chemoresistance. Liver CSCs dictate a hierarchical organization that shares both in tumorigenesis and organogenesis. A better understanding of the molecular signaling actions that regulate cellular hierarchy and success in defining key CSC-specific genes, which has opened up new avenues to accelerate the development of novel diagnostic and treatment strategies. This review highlights the molecular signaling networks associated with the pathogenesis of liver CSCs.
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