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Interventional effect of Piper betle aqueous extract in the progression of isoproterenol induced cardiac hypertrophy
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| Author:
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DOSS VA, SAVITHA KANNIYAPPAN, DHARANIYAMBIGAI KUBERAPANDIAN
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| Abstract:
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Piper betle (Piperaceae family) has potent anti-diabetic and antioxidant activities and is already reported to treat
cardiovascular diseases. This study assesses the intervening effect (anti-hypertrophic potential) of Piper betle(aqueous
extract) in the progression of cardiac hypertrophy induced by isoproterenol (ISO) in male Wistar rats. The
intervening efficacy of aqueous extract of P.betleleaves were investigated by its administration (300mg/kg b.w., oral, 7
days) to isoproterenol (10mg/kg b.w., i.p, 7 days) induced cardiac hypertrophy rats with comparison to the standard
drug losartan (50mg/kg b.w., oral, 7 days) whose hypertrophic status were confirmed by HW/BW ratio. Serum
analysis for the biochemical parameters namely total glucose, cholesterol, albumin, triglycerides, cardiac marker
enzymes (SGOT, SGPT, LDH) and enzymic antioxidants (SOD, catalase and GPx) were performed along with the
cardiac risk factor marker, homocysteine followed by the histopathological analysis of heart tissues. All data were
analyzed statistically. The biochemical parameters showed significantly(P<0.05) increased hypertrophic index
(HW/BW ratio) along with elevated levels of glucose, protein, cholesterol, SGOT, SGPT and LDH and significantly
decreased albumin, SOD, catalase, GPx. The study looked forward to investigate any abnormalities in homocysteine
levels in terms of cardiac hypertrophy and which was found to be significantly elevated in isoproterenol induced
hypertrophic rats that were remunerated by the administration of plant extract. This study showed that the aqueous
extract ofP.betle possess potent effect against the advancement to the state of cardiac hypertrophy. Besides it also
highlights the increased homocysteine and decreased albumin levels suggesting those as early markers of cardiac
hypertrophy irrespective of renal abnormalities. This potential of P.betleis postulated to be due to itsphytocompounds
eugenol and hydroxychavicol that require further isolation and characterization with reference to cardioprotective
medicinal values.
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| Keyword:
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Piper betle, eugenol, hydroxychavicol, cardiac protective, isoproterenol, cardiac hypertrophy.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.04.035
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| Download:
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