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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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Potential ActivityofNaringeninagainst Renal Ischemia Reperfusion Injury in Male mice

Author: WIDAD AL-JABBAR, HUSSEIN ABDULKADHIM, WADDAH MAHBOBA, GHIZAL FATIMA , NAJAH R HADI
Abstract: Acute renal failure is a result of renal ischemia, the development of chronic and advanced renal disorder and/or incomplete recovery of renal function are the consequent of acute renal failure,most surviving people are thought to return complete renal function despite a high mortality approximately 50%, the regeneration of renal tissue and function is attributed to the ability of the kidney to repair cellular damage aimingto investigate the potential activity of Naringenin in amelioration of renal ischemia reperfusion in male mice.Forty male Swiss Albino mice weighting 30-35 gram, 10-15 weeks were divided into four groups, ten mice in each group, animal groups are coordinated as follows: Group I (Sham group): the animals were subjected to the same anesthetic and surgical laparotomy but without induction of Ischemia Reperfusion Injury (IRI),Group II (Control group): exposed to bilateral renal IR procedure under anesthesia, Group III (Vehicle group): received vehicles sterile dimethyl sulfoxide (DMSO 0.2 %) alone intraperitoneal 30 minutes beforeexposed to renal IR procedures under anesthesia, Group IV (Naringenin treated group ): receivingNaringenin in a dose of 20 mg/kg intraperitoneal injection 30 minutes before exposed to IR procedure under anesthesia. At the end of reperfusion period, mice were sacrificed; blood samples were collected directly from thecarotid vein for determination of serum levels of urea andcreatinine. Bilateral nephrectomy was done and homogenized for measurements of tissue markers (TLR-2, NF-KB, MCP-1, HMGB-1 and F2 Isoprostane)and before homogenization part of the kidneys was fixed in formalin for histological examination. The Naringenin attenuates renal ischemia reperfusion injury through their pleiotropic effects via modulation of the inflammatory pathway and oxidativeactivity.
Keyword: Renal Ischemia, Reperfusion Injury,Naringenin, F2-Isoprostane
DOI: https://doi.org/10.31838/ijpr/2019.11.04.079
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