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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis and Charecterization of New Chalcone-Azo Ligands and Its Transition Metal Mixed Ligands Complexes with A Cytotoxic Activity study of Pd (II) Complex

Author: AFAQ KADHIUM, S.M. MAHDI, FAEZ. AALRAMAHI
Abstract: This study includes the synthesis of new Chalcone-Azo ligands and their mixed ligands bidentate (N,N) complexes, one of them named 3-(4-bromophenyl)-1-(3- (E )–(4,5-diphenyl-1H-imidazol-2-yl) diazenyl) phenyl) prop-2-en-1-one (LA) and the other named 3-(4-bromophenyl)-1-(3-(E)–(4,4'-methoxy-4,5-diphenyl-1Himidazol- 2-yl)diazenyl)phenyl)prop-2-en-1-one(LB). Both ligands were coordinated with (Co, Ni, Cu, Zn, Cd, Hg and Pd)(II) with mole ratio (1:1:1) as a mixed ligands Complexes. The ligands were characterized with many spectrometric techniques as(UV-Visible, FTIR, 1H &13C NMRs, Mass, and elementary analysis (C.H.N),while their mixed ligands complexes was characterized with some of the obvious techniques, indeed to the measurement of the electrical molar conductivity and magnetic susceptibility) to suggest their geometries. The results of this study has suggested an octahedral geometry for all complexes except the Pd(II) complex was square planer. The cytotoxicity of Pd(II) complex against human breast cancer( MCF-7 and AMJ-13) and normal cells (HBL) were examined, which indicated the significant effect of this complex on inhibition growth of cancerous cells, as result it may exploit in the clinical domain.
Keyword: Azo Compounds, Azo-Chalcone, Mixed Ligand Complexes.
DOI: https://doi.org/10.31838/ijpr/2019.11.04.075
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