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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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The Protective Impact of Vitamin C (Ascorbic acid) against Indomethacin-induced Renal Injury in Embryos andNeonatal (Newborns) Kidneys of White Female Rats During Pregnancy

Author: DALAL KAZEM, DR. SAHER MAHMOOD JAWD ALJAMALI
Abstract: This study wasperformedin the Labs of the Animal House in the Department of Biology/ Faculty of Education for Girls / University of Kufa from the period 1/2/2018 to 1/7/2018.Forty female adult rats with average weight of 135.5 g and 12 weeks,and forty fertile maleratswith age of 12 weeks .As for the purpose of obtaining pregnant rats females,the fertilemale rats were placed with female rats for matting, and then (40) pregnant female ratswere divided into two main groups,eachof them was consisted of (20) pregnant female ratsdivided into four subgroups, each subgroup was contained5 pregnant females,all pregnantfemale ratswere orally treated with one dose daily from the first day of pregnancy until the birth,thenthe pregnantfemale rats in first main group were dissected inday(20) of pregnancy for obtaining of prenatal embryos,while thepregnantfemale rats in second main group were remained until the birth for obtaining postnatal newborns. Moreover, prenatal embryos atday (20)of pregnancyand postnatal newborns were dissected for obtaining the kidneys (left and right),weights of these kidneys were measured, andthen the histological sections of these kidneyswere prepared. The results of the study showed a significant decrease (P <0.05) in the weights of the kidneys (left and right) of embryos in day (20) of pregnancy (prenatal) and postpartum newbornsin the groups that treated with indomethacinat a concentration of 8.40 mg / kg when compared with the control groupsand the other groups that administrated with vitamin C at a concentration of 85 mg / kg,as well as with vitamin C at a concentration of 85 mg / kg + indomethacin at a concentration of 8.40 mg / kg respectively,whereasthe experimental groups that subjected to vitamin C at a concentration of 85 mg / kg,and with vitamin C at a concentration of 85 mg / kg + indomethacin at a concentration of 8.40 mg / kg were indicated a significant increase (P <0.05) in the weights of the kidneys (left and right) of the embryos in day (20)of pregnancy (prenatal) and postpartum newborns in compared to the control groups,converselythere was no notablechanges (P> 0.05) between them. On the other hand, the histological study did not demonstrate any pathological -histologicalalteration in the cortex and medulla ofkidneysof embryos in day(20) of pregnancy (prenatal) and postpartum newborns inthe groups that submitted to vitamin C at a concentration of 85 mg / kg,and with vitamin C at a concentration of 85 mg / kg + indomethacin at a concentration of 8.40 mg / kg in comparison tothe control groups and the other study groups that treated with indomethacin at a concentration of 8.40 mg / kg,while the findings showed different patho-histologicalvariations in the cortex and medulla ofkidneys of embryos in day(20) of pregnancy (prenatal) and postpartum newborns in the groups that treated with indomethacin at a concentration of 8.40 mg / kg when compared with the control groups. The aim of current study to indicate the possible role of vitamin C in protection of the kidneys of embryos in day (20) of pregnancy (prenatal) and postpartum newborns from the pathological changes that stimulated byindomethacindrugin femaleratsduringpregnancy.
Keyword: Vitamin C, Indomethacin, Pregnancy, Birth, Kidneys, Embryos, Newborns.
DOI: https://doi.org/10.31838/ijpr/2019.11.04.074
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