IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

Current Issue
22nd NATIONAL CONVENTION

22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit


For More Detail Visit ncsp.ganpatuniversity.ac.in
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPRT ISSUE

January - March 6 [1] 2014

Click to download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Formulation and Evaluation of Delayed Release Capsule of Dimethyl Fumarate with Novel Technology

Author: ANJALI KUMARI, RAJESH KUMAR, BALWAN SINGH
Abstract: Dimethyl fumarate is an anti-inflammatory agent which is indicated for the treatment of multiple sclerosiswith relapsing formsand for psoriasis. The aim of this study was to prepare and evaluate delayed release capsule of Dimethyl fumarate with raft technology to reduce the flushing, a common side effect. The core mini tablets were prepared by direct compression method &enteric coating was done by perforated coating pan. Preformulation studies like angle of repose, bulk density, tapped density, Carr's index,Hausner's ratio & angle of repose were carried out. Evaluation of Post compression parameters such as Hardness, thickness, friability, weight variation disintegration and dissolution. The F05 batch shows the highest drug release at 45 min in pH 6.8 phosphate buffer was 97.13 % which are the satisfactorily results. After that encapsulation done which contains enteric coated mini tablets along with raft blend sothe formulation was formed a complex gel like structure in which mini tablets are trapped and dropped one by one with specified time interval. The F05 was the optimized batch among all six batches & blend 01 among all five blends are selected as per result. The raft technology was successfully applied on delayed release capsule increaseslag time thus decreasing flushing. Stability studies indicated that the developed dosage form was stable and retained their pharmaceutical properties at room temperature and accelerated conditions.
Keyword: Dimethyl fumarate, Raft technology, Delayed release capsules, Relapsing Remitting multiple sclerosis.
DOI: https://doi.org/10.31838/ijpr/2019.11.04.073
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
Pharmacovigilance: Current Scenario and Emerging Trends

National Conference sponsored by GUJCOST on 03.08.2019 at SNLPCP, Umrakh

Download Brochure
News & Events
0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free
0.07
2017CiteScore
 
11th percentile
Powered by  Scopus