IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
No Data found.
Article In Press
Life review of elderly depression
Development and application of ATR-FTIR spectroscopy for mixture homogeneity in pharmaceutical application
The Increasing Damage in Tubular Cell of Infant Mice’s Kidneys from Carbofuran Exposure during its Mothers’ Lactation Period
Trend of transsexualism problem and its implications towards muslim community in Malaysia
Development and validation of RP-HPLC method for the estimation of pidotimod in tablet dosage form
Evaluation of neurotoxicity of the ethanolic bark extract of Holarrhena pubescens Wall. ex G.Don in mice
Design, synthesis and evaluation of 2-aminobenzimidazole derivatives: strong candidate for PPAR gamma agonists.
Prediction of Heart Disease Using Feature Selection and Random Forest Ensemble Method
Strategies for Antiviral Drugs from Plants by Targeting the Hemagglutinin, Neuraminidase and other receptors of Influenza A virus
The impact of human resource and quality management in health care: A Review
12345678910...
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Optimization of Sonication Time on Physical Characteristics of Nanoemulsion on Mangosteen Rind (Garcinia Mangostana L.) Fraction

Author: NI AYU, PUTU SANNA YUSTIANTARA, NI WAYAN SINTA DARMA ENI
Abstract: The mangosteen rind fraction when formulated as a topical preparation requires a delivery system to support the absorption and penetration of the active substances. The delivery system used is nanoemulsion. Nanoemulsion is a form of disperse oil and water with particle dispersion sizes less than 100 nm, with a transparent appearance. The physical characteristics of nanoemulsion are closely related to particle size, so the particle size in nanoemulsions is important to know. Reduction of particle size to nanometer through sonication process, so that in this study optimization of sonication time was carried out and to know the relationship of sonication time to the physical characteristics of nanoemulsion. Nanoemulsion is made using the Self-Nanoemulsifying Drug Delivery System (SNEDDS). Nanoemulsion was made using mangosteen rind fraction of 0.125% with carriers olive oil, cosurfactant (PEG 400), and surfactant (Cremophor RH 40) with a fixed ratio of 1: 7: 2. The test results showed that the use of sonication time 15, 45 and 90 minutes produced nanoemulsion that met the physical characteristics of nanoemulsion is no phase separation, the percent transmittance were 94.933 ± 0.802%, 96.1 ± 0.458%, and 92.167 ± 0.416%; test results of particle size 20.38 ± 0.090 nm, 19.693 ± 0.070 nm and 31.637 ± 1.591 nm; the potential zeta test results were 5.14 ± 0.57 mV, - 5.683 ± 0.291 mV, and -5.097 ± 0.076 mV.
Keyword: Fraction, Mangosteen, Nanoemulsion, SNEDDS, Sonication time
DOI: https://doi.org/10.31838/ijpr/2019.11.04.052
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free