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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

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A review on compatibility study of sucralfate and metoprolol succinate for the formulation of bilayer floating tabletas a GRDDS.

Author: SREEDHAR DAS, DR BIBHUTI BHUSANA PANIGRAHI, DR MANOJ KUMAR PANI
Abstract: This review focus upon compatibility study of Sucralfate and Metoprolol Succinate being administrated as Bilayer floating tablet and its implementation in treatment of ulceration and hypertension in pregnancy.This review is prepared by focusing upon,characteristics study of Sucralfate and Metoprolol succinate, Drug interaction between the two drugs and study about fulfilment of criteria of Bilayered floating tablet. The ulcer protective Sucralfare is simpler and more effective H2 blockers and antihypertensive Metoprolol succinate the ß1 receptor blocker fulfilling all the criteria of Bilayer floating tablet .They can be implemented in case of pregnancy and lactation as a combined form in empty stomach .As bi layered floating tablet Sucralfate can act as immediate release layer and Metoprolol Succinate can act as sustained release layer and improve the controlled delivery of drug for prolonged period of time at desired rate and improve the bioavailability and which ideal doses form attains the desired therapeutic concentration of drug in plasma and maintains constant frequency for entire duration of treatment.
Keyword: Sucralfate, Ulcerprotective, Antihypertensive, Metoprolol Succinate, Bilayered floating tablet.
DOI: https://doi.org/10.31838/ijpr/2019.11.04.024
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