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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Controlled release of methotrexate using alpha-lactalbumin microparticles.

Author: UPLOADED BY-ADMIN, VIJAYARAGAVAN S, VINO S, LOKESH KR, GHOSH AR, JAYARAMAN G
Abstract: Microparticles of a -lactalbumin, in the free and methotrexate encapsulated forms were prepared by emulsifying an aqueous solution of a -lactalbumin in 1% ethylcellulose in chloroform at 4°C. The particles were further stabilized by cross linking with glutaraldehyde. The size of the particles was found to be in the range of 0.5 to 2µm, with an average size of 1 µm. Both free and methotrexate encapsulated a -lactalbumin microparticles were analyzed by differential scanning calorimetry and X-ray diffraction studies. The rate of drug release was investigated by in vitro dissolution studies using UV spectroscopy. The results indicate that these a -lactalbumin microparticles are capable of controlled and sustained release of methotrexate up to a maximum time of 36 h in PBS at pH 7.4. The study introduces a -lactalbumin as a novel drug carrier and its potential to combat the failure of free methotrexate administration.
Keyword: a-Lactalbumin(ALA), Controlled release, Methotrexate, Microparticles, Milk protein, Soluble drugs, Steric stabilization
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0.12
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