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Controlled release of methotrexate using alpha-lactalbumin microparticles.
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| Author:
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UPLOADED BY-ADMIN, VIJAYARAGAVAN S, VINO S, LOKESH KR, GHOSH AR, JAYARAMAN G
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| Abstract:
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Microparticles of a -lactalbumin, in the free and methotrexate encapsulated forms were prepared by emulsifying an
aqueous solution of a -lactalbumin in 1% ethylcellulose in chloroform at 4°C. The particles were further stabilized by cross
linking with glutaraldehyde. The size of the particles was found to be in the range of 0.5 to 2µm, with an average size of 1
µm. Both free and methotrexate encapsulated a -lactalbumin microparticles were analyzed by differential scanning calorimetry
and X-ray diffraction studies. The rate of drug release was investigated by in vitro dissolution studies using UV spectroscopy.
The results indicate that these a -lactalbumin microparticles are capable of controlled and sustained release of methotrexate
up to a maximum time of 36 h in PBS at pH 7.4. The study introduces a -lactalbumin as a novel drug carrier and
its potential to combat the failure of free methotrexate administration.
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| Keyword:
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a-Lactalbumin(ALA), Controlled release, Methotrexate, Microparticles, Milk protein, Soluble drugs, Steric stabilization
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| EOI:
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| DOI:
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