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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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Comparative study of the polyphenol content related-antioxidant and anti-inflammatory activities of methanolic extracts from different parts of Hertia cheirifolia

Author: KATIA ABDELOUHAB, SANA AOUACHRIA, THORAYA GUEMMEZ, NOUREDDINE CHAREF, ABDERRAHMANE BAGHIANI, HAYETTE LOUAÏLECHE, RYSZARD AMAROWICZ, LEKHMICI ARRAR
Abstract: Hertia cheirifolia is one of the endemic Mediterranean medicinal plants, belonging to the Asteraceae family. This plant is traditionally used for its therapeutic effects on digestive disorders and wound healing. In the present study, the total phenolic and flavonoid contents of methanolic extracts from leaves, stems, flowers and roots of Hertia cheirifolia were evaluated using the Folin-Ciocalteu reagent and AlCl3 methods repectively. Their antioxidant activity was then assessed by measuring the capacity to scavenge the free radical ABTS•+. The ferric reducing antioxidant power (FRAP) and the inhibition of ß-carotene bleaching were also estimated for each extract. The anti-inflammatory activity was tested using the PMA-induced ear oedema model in mice. The leaf extract contained the highest amounts of polyphenols (50.61 ± 6.21 mg GAE/g) and flavonoids (9.75 ± 0.03 mg QE/g). The leaf extract also displayed the most potent antioxidant capacity against the ABTS•+ cation radical (IC50 = 76.48 ± 0.58 µg/mL) and the highest ferric reducing power (307 ± 3 µmol. Fe2+ Eq/g). However, all extracts showed approximately 65% inhibitory activity against ß-carotene bleaching. Finally, the stem and root extracts exerted the strongest (~ 50%) anti-inflammatory effect in mice with ear oedema. These results revealed that all Hertia cheirifolia parts are a valuable source of polyphenols with potent antioxidant and anti-inflammatory properties.
Keyword: Hertia cheirifolia, polyphenols, flavonoids, antioxidant activity, anti-inflammatory activity.
DOI: https://doi.org/10.31838/ijpr/2019.11.04.034
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