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Comparative study of the polyphenol content related-antioxidant and anti-inflammatory activities of methanolic extracts from different parts of Hertia cheirifolia
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| Author:
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KATIA ABDELOUHAB, SANA AOUACHRIA, THORAYA GUEMMEZ, NOUREDDINE CHAREF, ABDERRAHMANE BAGHIANI, HAYETTE LOUAÏLECHE, RYSZARD AMAROWICZ, LEKHMICI ARRAR
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| Abstract:
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Hertia cheirifolia is one of the endemic Mediterranean medicinal plants, belonging to the Asteraceae family. This plant is
traditionally used for its therapeutic effects on digestive disorders and wound healing. In the present study, the total
phenolic and flavonoid contents of methanolic extracts from leaves, stems, flowers and roots of Hertia cheirifolia were
evaluated using the Folin-Ciocalteu reagent and AlCl3 methods repectively. Their antioxidant activity was then
assessed by measuring the capacity to scavenge the free radical ABTS•+. The ferric reducing antioxidant power (FRAP)
and the inhibition of ß-carotene bleaching were also estimated for each extract. The anti-inflammatory activity was
tested using the PMA-induced ear oedema model in mice. The leaf extract contained the highest amounts of
polyphenols (50.61 ± 6.21 mg GAE/g) and flavonoids (9.75 ± 0.03 mg QE/g). The leaf extract also displayed the most
potent antioxidant capacity against the ABTS•+ cation radical (IC50 = 76.48 ± 0.58 µg/mL) and the highest ferric
reducing power (307 ± 3 µmol. Fe2+ Eq/g). However, all extracts showed approximately 65% inhibitory activity against
ß-carotene bleaching. Finally, the stem and root extracts exerted the strongest (~ 50%) anti-inflammatory effect in
mice with ear oedema. These results revealed that all Hertia cheirifolia parts are a valuable source of polyphenols with
potent antioxidant and anti-inflammatory properties.
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| Keyword:
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Hertia cheirifolia, polyphenols, flavonoids, antioxidant activity, anti-inflammatory activity.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.04.034
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| Download:
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