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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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The effects of gabapentin and ibuprofen on pain and reduction of morphine consumption in patients suffering from orthopedic fractures admitted in hospital emergency room

Author: PARVIN KASHANI, AMIN SABERINIA
Abstract: Pain is an unpleasant experience after surgery, especially in surgery and orthopedic fractures, for which opiate drugs are used to control it, but its use is limited due to side effects. The aim of this study was to compare the effect of gabapentin and ibuprofen on pain and reduction of morphine consumption in patients with orthopedic fractures admitted to Emam Khomeini Hospital, Tehran. This study was a prospective, double-blind, clinical trial. Eighty-eight patients with an orthopedic fracture who met the inclusion criteria were selected and randomly divided into 4 groups of 22 patients. Patients received placebo capsules and tablets (Group A), ibuprofen tablets (400 mg) and placebo capsules (Group B), placebo tablets and gabapentin capsules (group C), and capsules gabapentin (600 mg) and ibuprofen tablets (group D). Pain relief (based on VAS criterion) and reduction in morphine requirement were assessed at 0, 2, 6, 12, 18 and 24 hours after initiation of treatment. The results illustrated that the mean of morphine prescription at 2, 6, 12, 18 and 24 hours was significantly different as compared with admission time (p = 0.001). Morphine intake in these groups was as gabapentin/ibuprofen> gabapentin> ibuprofen> placebo.Mean systolic blood pressure in patients at 6,8 and 24 hours after treatment was significantly different when comparing with second hour and mean diastolic blood pressure at 6, 12, 18, and 24 hours after treatment was also found to be significantly different. Comparison with the second hour (p <0.05).The findings suggests that administration of ibuprofen in combination with gabapentin can be capable of reducing pain and morphine application. In addition, administration of these drugs was not found to be associated with any side effect and administration of analgesic dose of gabapentin was effective in preventing morphine tolerance and dependence. Evaluation of pain reduction estimates suggested that gabapentin can be helpfully applicable for preventing acute pain.
Keyword: Gabapentin, ibuprofen, placebo, pain, morphine, orthopedic fractures, emergency.
DOI: https://doi.org/10.31838/ijpr/2019.11.04.032
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