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Oxidation of Capecitabine - anticancer drug by potassium ferrate (VI) in alkaline medium: A kinetic and mechanistic approach.
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| Author:
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VIDYAVATI SHASTRY, S. YAMUNA PRINCY
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| Abstract:
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The kinetics and mechanism of oxidation of capecitabine by potassium ferrate (VI) in the alkaline medium were
investigated spectrophotometrically under pseudo-first-order condition. Experimental results indicated that the
reaction exhibits first-order concerning to capecitabine, first-order concerning to potassium ferrate (VI) and negative
fractional-order concerning to OH- ion. The effect of ionic strength of the medium on the reaction rate has been
studied. The kobs value decrease with an increase in the ionic strength due to the presence of negative charge in one
of the reactant. The negative charge reduces the ability of ion to encounter another reactant. The reaction exhibits
1:1 stoichiometry. Oxidation products are identified by LC-MS and spot test. Activation parameters are calculated
and tabulated. A general scheme involving intermediate formation coupled with two-electron oxidation has been
proposed to explain the experimental data. Rate equation is derived to account for the observed kinetic data and rate
constants of the rate-controlling step were calculated.
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| Keyword:
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Kinetics, oxidation, Capecitabine, Potassium ferrate (VI), Mechanism.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.04.022
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| Download:
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