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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Oxidation of Capecitabine - anticancer drug by potassium ferrate (VI) in alkaline medium: A kinetic and mechanistic approach.

Author: VIDYAVATI SHASTRY, S. YAMUNA PRINCY
Abstract: The kinetics and mechanism of oxidation of capecitabine by potassium ferrate (VI) in the alkaline medium were investigated spectrophotometrically under pseudo-first-order condition. Experimental results indicated that the reaction exhibits first-order concerning to capecitabine, first-order concerning to potassium ferrate (VI) and negative fractional-order concerning to OH- ion. The effect of ionic strength of the medium on the reaction rate has been studied. The kobs value decrease with an increase in the ionic strength due to the presence of negative charge in one of the reactant. The negative charge reduces the ability of ion to encounter another reactant. The reaction exhibits 1:1 stoichiometry. Oxidation products are identified by LC-MS and spot test. Activation parameters are calculated and tabulated. A general scheme involving intermediate formation coupled with two-electron oxidation has been proposed to explain the experimental data. Rate equation is derived to account for the observed kinetic data and rate constants of the rate-controlling step were calculated.
Keyword: Kinetics, oxidation, Capecitabine, Potassium ferrate (VI), Mechanism.
DOI: https://doi.org/10.31838/ijpr/2019.11.04.022
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