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Association of Ghrelin Levels with Insulin Resistance in Iraqi Patients with Myocardial Infarction
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| Author:
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HAMSAGHWAMER GHAZI, NAWALM.J.AL-SHAMMAA
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| Abstract:
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Ghrelin, a peptide hormone is accountable for alteration in energy balance pretentious by nutrition and growth
hormone secretion. Furthermore, it too controls glucose metabolism. Revisions have proposed that ghrelinlevels
change in diverse functional disorders such as heart diseases and diabetes mellitus. The aspire of the study was to
equate the ghrelin concentrations in myocardial infarction patients with and without diabetes and to examine if there
is any relationship between ghrelin and insulin resistance. A entire number of 150individuals were conducted in the
study, among them 50 myocardial infarction patients were suffering from type 2 diabetes mellitus, 50 myocardial
infarction patients were not suffering from diabetes, and 50 were healthy as control group. Fasting serum glucose,
lipid profile, urea, creatinine, serum insulin, and ghrelin levels were measured. There was a significant rise(p< 0.05) in
fasting serum glucose, all lipids except high density lipoprotein cholesterol, urea, and creatinine in myocardial
infarction patients with type 2 diabetes as paralleled to the control. Moreover, there was a substantial reduction (p<
0.05) in serum ghrelin inmyocardial infarction patients with and without diabetes as compared to the controls
[19.15±4.77 (diabetic), 21.19±4.09 (non-diabetic), 30.46±7.54 (control)]. Insulin resistance was detected in myocardial
infarction patients and was connected with a cardiovascular risk features, an adverse disease progression and impaired
lipid metabolism. This revision illustrated that hyperglycemia might result in defeat of ghrelin levels in type 2 diabetic
patients.
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| Keyword:
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Myocardial infarction, Insulin resistance, lipid profile, Ghrelin.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.04.018
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| Download:
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