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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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Association of Ghrelin Levels with Insulin Resistance in Iraqi Patients with Myocardial Infarction

Author: HAMSAGHWAMER GHAZI, NAWALM.J.AL-SHAMMAA
Abstract: Ghrelin, a peptide hormone is accountable for alteration in energy balance pretentious by nutrition and growth hormone secretion. Furthermore, it too controls glucose metabolism. Revisions have proposed that ghrelinlevels change in diverse functional disorders such as heart diseases and diabetes mellitus. The aspire of the study was to equate the ghrelin concentrations in myocardial infarction patients with and without diabetes and to examine if there is any relationship between ghrelin and insulin resistance. A entire number of 150individuals were conducted in the study, among them 50 myocardial infarction patients were suffering from type 2 diabetes mellitus, 50 myocardial infarction patients were not suffering from diabetes, and 50 were healthy as control group. Fasting serum glucose, lipid profile, urea, creatinine, serum insulin, and ghrelin levels were measured. There was a significant rise(p< 0.05) in fasting serum glucose, all lipids except high density lipoprotein cholesterol, urea, and creatinine in myocardial infarction patients with type 2 diabetes as paralleled to the control. Moreover, there was a substantial reduction (p< 0.05) in serum ghrelin inmyocardial infarction patients with and without diabetes as compared to the controls [19.15±4.77 (diabetic), 21.19±4.09 (non-diabetic), 30.46±7.54 (control)]. Insulin resistance was detected in myocardial infarction patients and was connected with a cardiovascular risk features, an adverse disease progression and impaired lipid metabolism. This revision illustrated that hyperglycemia might result in defeat of ghrelin levels in type 2 diabetic patients.
Keyword: Myocardial infarction, Insulin resistance, lipid profile, Ghrelin.
DOI: https://doi.org/10.31838/ijpr/2019.11.04.018
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