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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The Impact of methylenetetrahydrofolate reeducates gene polymorphisms on Iraqi patients with diabetic nephropathy

Author: SAFA. ALI, ZAYNAB.A.RAZZAQALSHARIFI, ALI.E.ELAWY
Abstract: Diabetic nephropathy is a major cause of end-stage renal disease. Micro albuminuria is a term to describe a moderate increase in the level of urine albumin. It occurs when the kidney leaks mall amounts of albumin into the urine . The aim of this study was to investigate the influence of the C677T and A1298C polymorphisms of methylene tetrahydrofolate on the progression of chronic kidney disease in diabetic nephropathy of Iraqi patients to delay the deterioration in renal function. A hospital-based case-control study was performed. A total of 60 patients with diabetic nephropathy age (24-87) and 60 controls age(16-68) selected from nephrology center in Bagdad Teaching Hospital /Medical City from December 2017 until the end of August 2018,the result shows mean differences of study markers including ( FBS, Blood urea, Serum creatinine and MTHFR) according to type of albuminuria (micro albuminuria and macro albuminuria) among patients with diabetic nephropathy. There were significant differences between means of Blood urea and Serum creatinine according to study group. in result conclusion Urinary biomarkers were significantly elevated in normoalbuminuric type 2 diabetic patients compared with nondiabetic control subjects and could be used as markers of diabetic nephropathy( DN) at a very early stage even before the development of micro albuminuria.
Keyword: micro albuminuria.
DOI: https://doi.org/10.31838/ijpr/2019.11.04.016
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