|
Synthesis and characterization of some new Pyrazolin,Triazolin and Tetrazolin derivatives of 1,8- naphthal imide and evaluate their anti-microbial activity
|
|
| Author:
|
MOHAMMED AL-KHUZAIE, AAD M.H. AL-MAJIDI
|
| Abstract:
|
New pyrazolin, triazolin and tetrazolin derivatives of 1,8-naphthalimide had been synthesized from 1, 8-naphthalic
anhydride by reactionwith p-phenylenediamine to give 1,8-naphthalimide derivative [1], that converted into its
diazonium salt derivative by using sodium nitrite and acetic acid. Then, the diazonium salt reacted at the first time
with acetylacetone to give compound [2] that react with hydrazine derivative to produce pyrazolin derivatives [3-7].
At the second time, diazonium salt reacted with sodium azide to produce azide derivative [8] that react with
????unsaturated carbonyl compounds to obtained 1,2,3-triazolin derivatives [9-13]. Also, azide derivative [8] react
with some of Schiff’s bases derivatives [14-18] of compound [1] to produce tetrazolin derivatives [19-23].
The New pyrazolin, triazolin,andtetrazolin derivatives had been identified by [1H-NMR, 13C-NMR, and FTIR] and by
measuring of characteristic physical properties and specific reactions. Moreover, the biological effect of all prepared
compounds was tested on fungicidal and some of the bacteria.
|
| Keyword:
|
1,8-naphthalic anhydride, triazolin, tetrazolin, pyrazolin, anti-microbial activity.
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2019.11.04.015
|
| Download:
|
Request For Article
|
|
|