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Article Detail
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Synthesis and characterization of new 1,2,4-triazole, Oxazoline and Thiazoline derivatives from 2,5 dimarcaptothiadiazole
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| Author:
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MOHAMMAD R. AHMED
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| Abstract:
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This research includes the synthesis of new heterocyclic containing 1,2,4-triazole, oxazoline and thiazoline derivatives
of 2,5 dimarcaptothiadiazole . The preparation process started by the reaction of 2,5 dimercapto 1,3,4 thiadiazole (1)
with ethyl chloroacetate to give diethyl 2,2`-(1,3,4-thiadiazole-2,5-diyl)bis(sulfanediyl)diacetate (2). Compound (2)
reacted with hydrazine hydrate to give 2,5 bis(mercapto acetichydrazide) 1,3,4 thiadiazole(3). Compound (2) reacted
with thiosemicarbazide to give 2,2'-(2,2'-((1,3,4-thiadiazole-2,5-diyl)bis(sulfanediyl))bis(acetyl))bis(hydrazine-1-
carbothioamide) (2a). Compound (3) reacted with (phenylisocynate or phenylisothiocynate) to give 2,2`-( 2,2`-((1,3,4-
thiadiazole-2,5-diyl)bis(sulfanediyl))bis(N-phenylhydrazine-1-carboxamide) and 2,2`-( 2,2`-((1,3,4-thiadiazole-2,5-
diyl)bis(sulfanediyl))bis(N-phenylhydrazine-1-carbothioamide) (4-5). Compounds (2a,4,5) reacted with 4N sodium
hydroxide solution to give 1,2,4-triazole (2b,4a,5a). Compounds (4 or 5) reacted with (p-bromophenacyl bromide and
p-phenylphenacyl bromide) to give oxazoline (6,7) and thiazoline (8,9) derivatives.
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| Keyword:
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triazole, oxazoline, thiazoline
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.04.011
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| Download:
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