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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Interfacial and Thermodynamic Properties of Tween 80 Surfactant-Ibuprofen Drug System

Author: MARYAM A.AZEEZ, SAMEER H. KAREEM
Abstract: Interfacial and thermodynamic propertiesGmax,Amin, ?cmc ,?G° ads,?G° m, ?H° m, and ?S° m of individual Tween 80 (TW 80) surfactant and their mixture with Ibuprofen (IBU) drug at two concentrations (0.0001 and 0.00001 M) have been calculated. The calculation was performed using the surface tension at temperature range 293-323 K with the variation of surfactant concentration to determine the cmc of all systems studied. The variation of critical micelle concentration (cmc) with concentration of Ibuprofen drug and the temperature was used to calculate theparameters above. The results indicate that the cmc of TW 80 increase when the IBU was added and when the temperature increased at the whole temperature studied. The results obtained for interfacial properties show that Gmax decrease with the addition of IBU and increases with temperature increases. The results of thermodynamic properties indicate that the micellization and adsorption at interface are spontaneous and the ?G°adsare more negative than ?G°mat all temperatures which reveal that micelle formation is less spontaneous than adsorption or surface adsorption is more preferable than micellization.
Keyword: Tween80, Ibuprofen, critical micelle concentration, interfacial properties
DOI: https://doi.org/10.31838/ijpr/2019.11.04.009
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