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Interfacial and Thermodynamic Properties of Tween 80 Surfactant-Ibuprofen Drug System
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| Author:
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MARYAM A.AZEEZ, SAMEER H. KAREEM
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| Abstract:
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Interfacial and thermodynamic propertiesGmax,Amin, ?cmc ,?G°
ads,?G°
m, ?H°
m, and ?S°
m of individual Tween 80 (TW 80)
surfactant and their mixture with Ibuprofen (IBU) drug at two concentrations (0.0001 and 0.00001 M) have been
calculated. The calculation was performed using the surface tension at temperature range 293-323 K with the
variation of surfactant concentration to determine the cmc of all systems studied. The variation of critical micelle
concentration (cmc) with concentration of Ibuprofen drug and the temperature was used to calculate theparameters
above. The results indicate that the cmc of TW 80 increase when the IBU was added and when the temperature
increased at the whole temperature studied. The results obtained for interfacial properties show that Gmax decrease
with the addition of IBU and increases with temperature increases. The results of thermodynamic properties indicate
that the micellization and adsorption at interface are spontaneous and the ?G°adsare more negative than ?G°mat all
temperatures which reveal that micelle formation is less spontaneous than adsorption or surface adsorption is more
preferable than micellization.
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| Keyword:
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Tween80, Ibuprofen, critical micelle concentration, interfacial properties
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.04.009
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| Download:
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