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New method for the evaluation of propranolol with phosphotungstic acidvialong distance chasing photometer (NAG-ADF-300-2) using continuous flow injection analysis
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| Author:
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ELHAM MEZAAL, NAGAM S. TURKEY
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| Abstract:
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A new, simple and sensitive method was used forevaluation of propranolol withphosphotungstic acidto prove the
efficiency, reliability and repeatability of the long distance chasing photometer (NAG-ADF-300-2) using continuous
flow injection analysis. The method is based on reaction between propranolol and phosphotungstic acid in an aqueous
medium to obtain a yellow precipitate. Optimum parameters was studied to increase the sensitivity for developed
method. A linear range for calibration graph was 0.007-13 mmol/L for cell A and 5-15 mmol/L for cell B, and LOD
207.4792 ng/160 µL and 1.2449 µg/160 µL respectively to cell A and cell B with correlation coefficient (r) 0.9988 for
cell A, 0.9996 for cell B, RSD% was lower than 1%, (n=8) for the determination of propranolol at concentration ( 5,7
and 10) mmol/L respectively to cell A and cell B. The results were compared with classical methods UVSpectrophotometric
at ?max=289 nm and turbidmetric method by using method standard addition via t-test at 95%
level confidence. The comparison of dataexplain that long distance chasing photometer (NAG-ADF-300-2) is the
choice with excellent extended detection and wide application.
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| Keyword:
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Propranolol, Attenuation of light, Continuous flow injection analysis, Turbidity,
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.04.008
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| Download:
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