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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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The Protective Activity of Broccoli Alcoholic Extract Against Augmentin effects In white Albino Male Rats

Author: NOOR AL-QARAGHULIA, SAHERMAHMOODJWADALJAMALIB, ESRAA MAHDI ZAHID
Abstract: The current investigation has been performed in the animal house of (Biology department) that belonged to the Faculty of Education for "Girls" to evaluate the possible improvable impacts of Broccoli alcoholic extract on regression of the functional performance of hepatocytes and the oxidative stressparameters that induced by Augmentin antibiotic, soforty males of laboratory rats were related to(Sprague – Dawley) strain used in the this study, divided into four treated groups equally, the first wascontrol(normal group),therefore orally treated with normal saline (0.9% solution),and the second group was administrated with625 mg/kg of Augmentin orally, as well as the third group was orally given100mg/kg of Broccoli alcoholic extract + Augmentin625 mg/kg, in addition tothe forth group that was receivedBroccoli alcoholic extract 100mg/kg orally .Moreover, the treatments of this study had been continued for seven days(one week)at once daily.Concern to the complete statistical analysis for the findingsof the present study,there was a significant elevation in the effectiveness of hepatic enzymes, and malondialdehyde (MDA), as well as total bilirubin levels,whilethe level of reduced glutathione(GSH) was notably decreased in the experimental group that was orally subjected to the Augmentin antibiotic when compared with the other groups of study .On the other hand, the two groups that submitted to Broccoli alcoholic extract Augmentin, and alcoholic extract of Broccoli only were revealed no desirablechanges in these indices in compared to the control group.The results of this study indicated to the protective andameliorative properties of alcoholic extract of Broccoli on the hepatic tissue functions and oxidative markers deterioration that caused byAugmentin antibiotic.
Keyword: Albino Male Rat; Augmentin ; Broccoli; Oxidative Stress.
DOI: https://doi.org/10.31838/ijpr/2019.11.04.004
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