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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Lactobacillus paracasei A26 mediated biosynthesis of silver nanoparticles and their antibacterial activity against CAUTIs pathogens

Author: AL-BASHEERA. H, AL-WANDAWIS
Abstract: The use of microorganisms for biosynthesis of silver nanoparticles (AgNPs) is considered the eco-friendly technology and cost-effective routes. The involvement of Lactobacillus spp. for biosynthesis of AgNPs offers a good bio-alternative, due to most of included members is classified as GRAS, and recently become a research topic in metal nanoparticles production. In this study, human enteric Lactobacillus paracasei A26 was used for biosynthesis of AgNPs. The nitrate reductase was mediated the reduction of Ag+ to Ag0. The Nano-scaled silver was achieved at 1mM AgNO3 precursor concentration, 37°C, and under visible light conditions. The surface Plasmon resonance found at 400 nm, confirmed the formation of Ag NPs. The particles showed spherical shape with size ranges 5-10 nm by TEM analysis. XRD analysis confirmed the crystalline nature of the particles. FTIR analysis was demonstrated the biomolecules responsible in bioreduction of silver ions. Antimicrobial assay verified bactericidal activity of biosynthesized AgNPs against CAUTIs pathogens, with highest efficacy against Gram- negative uropathogenes. The MIC values were ranged from 20 to30 µg/mL. Peudomonas.aeruginosa had the lowest MIC with a value of 20 µg /mL. Escherichiacoli, Klebsiella. pneumonia, Enterobactercloacae, Protease mirabilis and Staphylococcus aureus showed the MIC value of 25 µg/mL, while Serratiamarcescens, and Streptococcusagalactiae had the highest of all the MICs determined (30 µg/mL).
Keyword: Metal nanoparticles, silver nanoparticles, L. paracasei, CAUTIs pathogens, antibactericidal activity of AgNPs, and MIC
DOI: https://doi.org/10.31838/ijpr/2019.11.04.003
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