22nd National Convention of Society of Pharmacognosy & International Conference. AICTE Sponsored International Conference at Parul University.

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

Current Issue
22nd NATIONAL CONVENTION

22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit


For More Detail Visit ncsp.ganpatuniversity.ac.in
Article In Press
Biomechanical/biochemical factors contributing to cardiac fibrosis in the heart and engineered cardiac tissue
THE ASSOCIATION AND LINKGAGE OF VARIOUS RETROVIRUSES AND ITS PROGRESSION TOWARDS NEURODEGENERATION
Architecture of Viral RNA Helicases; HCV helicase as Antiviral Target
GC-MS analysis of rhizome extract by Cold maceration of Curcuma amada Roxb.
Development and Evaluation of Febuxostat Sublingual Tablet Formulation
Development and Evaluation of Febuxostat Sublingual Tablet Formulation
A comparative study of adaptogenic effect of Withania somnifera with Mifepristone (a GR antagonist) on chronic stress - induced perturbations in glucose metabolism
In Vitro Anticancer Activity Of Leaves Of Rumex Vesicarius Linn And Symplocos Racemosa Roxb By Trypan Blue Method
PREPARATION AND INVITRO CHARACTERISATION OF ANTIBACTERIAL NANOCAPSULES
Cytotoxic potential of the crude solvent extract of Botryodiplodia theobromae – an endophytic fungi isolated from Catharanthus roseus.
12
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IJPRT ISSUE

January - March 6 [1] 2014

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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Article Detail

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Synthesis of New oxazine and oxazocine derivatives and Evaluation of their Antiproliferative Potency against Different Cancer Cell Lines

Author: KHADIGA AHMED, HANAA A. TAWFIK, NAGWA M. FAWZY, SHWEEKAR I. EL NAEM, MAGDE S. ALY
Abstract: A new method was proceeding the synthesis of new oxazocine derivatives 4a, by a condensation reaction of: aldehyde 1, Meldrum’s acid 2, and isocyanate derivatives 3a, b in dichloromethane at room temperature. A novel isocyanate-based four-component reaction between an aldehyde 1, Meldrum’s acid 2, an isocyanate derivatives 10a-c and an aromatic phenol derivative 9a, b/ and or p-anisidine 9c was provided oxazocine derivatives 11a-i. A novel one-pot procedure of three-component reaction for the preparation oxazine-derivatives 13a-d was described by heating a mixture of an anthranilic acid, aldehyde 1, and an isocyanate derivatives 12a-d in methanol. All of the newly prepared compounds were evaluated as anti-cancer activity against hepatocellular carcinoma cell line HEPG2, breast carcinoma cell line MCF-7, prostate carcinoma cell line PC3. Anticancer activity results indicated that the synthesized products 4b, 11b, 13b, 11e and 11i showed growth inhibition activity against two of the tested cell lines (HEPG-2 and PC3) but with changing intensities extents against Doxorubicin as a reference anticancer drug. Our results also showed that all compounds did not have any activity against human breast MCF-7 cells. The results yielded a theoretical reference for the exploration of new anti-cancer agents and may be helpful in designing drugs for chemotherapy.
Keyword: Isocyanate, isothiocyanates oxazocine, multi-component reactions, oxazine, cytotoxicity, anticancer activity, human cancer cell lines.
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News & Events
22nd National Convention of Society of Pharmacognosy & International Conference. For more details visit https://ncsp.ganpatuniversity.ac.in
Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)