Impact Factor for Five Years is 1.55 (2012 - 2016). IJPRT Re-launched from 2017, for more details visit www.ijprtonline.com

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Article In Press
Analytical Method Development and Validation for the Simultaneous Estimation of Ambroxol Hydrochloride and Guaiphenesin in Syrup Dosage form by RP-HPLC
Role of NMDA receptor antagonist in ethanol withdrawal syndrome
STABILITY INDICATING LC-MS/MS METHOD FOR QUANTIFICATION OF IBRUTINIB IN HUMAN PLASMA
A review on drug: Amantadine
Chemopreventive and antioxidative activity of Carissa carandas extract against chemical induced skin tumorigenesis in mice
ROLE OF AMIODARONE IN ACUTE MYOCARDIAL INFARACTION INDUCED VENTRICULAR TACHYCARDIA IN PATIENTS WITH LEFT ANTERIOR DESCENDING ARTERY INVOLVEMENT
Extraction optimisation, fractionation, standardisation, in vitro antioxidant and anticholinesterase activity of fractions of Indian Propolis
Lung Cancer in Lifelong Never Smokers-Short Review
3D-Quantitative Structure Activity Relationship Study of Pyrazolothiazol-4-(5H)-One Derivatives as Epidermal Growth Factor Receptor Inhibitors
A Convenient strategy for the synthesis and characterisation of Biologically important Schiff bases encompassing Naphtho[2,1-b]thiophene carboxylic Acid
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IJPRT ISSUE

January - March 6 [1] 2014

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Synthesis of New oxazine and oxazocine derivatives and Evaluation of their Antiproliferative Potency against Different Cancer Cell Lines

Author: KHADIGA AHMED, HANAA A. TAWFIK, NAGWA M. FAWZY, SHWEEKAR I. EL NAEM, MAGDE S. ALY
Abstract: A new method was proceeding the synthesis of new oxazocine derivatives 4a, by a condensation reaction of: aldehyde 1, Meldrum’s acid 2, and isocyanate derivatives 3a, b in dichloromethane at room temperature. A novel isocyanate-based four-component reaction between an aldehyde 1, Meldrum’s acid 2, an isocyanate derivatives 10a-c and an aromatic phenol derivative 9a, b/ and or p-anisidine 9c was provided oxazocine derivatives 11a-i. A novel one-pot procedure of three-component reaction for the preparation oxazine-derivatives 13a-d was described by heating a mixture of an anthranilic acid, aldehyde 1, and an isocyanate derivatives 12a-d in methanol. All of the newly prepared compounds were evaluated as anti-cancer activity against hepatocellular carcinoma cell line HEPG2, breast carcinoma cell line MCF-7, prostate carcinoma cell line PC3. Anticancer activity results indicated that the synthesized products 4b, 11b, 13b, 11e and 11i showed growth inhibition activity against two of the tested cell lines (HEPG-2 and PC3) but with changing intensities extents against Doxorubicin as a reference anticancer drug. Our results also showed that all compounds did not have any activity against human breast MCF-7 cells. The results yielded a theoretical reference for the exploration of new anti-cancer agents and may be helpful in designing drugs for chemotherapy.
Keyword: Isocyanate, isothiocyanates oxazocine, multi-component reactions, oxazine, cytotoxicity, anticancer activity, human cancer cell lines.
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News & Events
Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)