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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Infusion therapy of experimental hemolytic anemia with a new domestic drug

Author: SHARIFA FAZILOVA, KHAMID YAKUBOVICH KARIMOV, TIMUR RAUFOVICH ALIMOV
Abstract: The use of traditional infusion-transfusion therapy is not always able to fully restore the body and prevent the development of irreversible changes in hemolytic anemia. The aim of the study was to evaluate the effectiveness of the new infusion drug "Reomannisol" in experimental hemolytic anemia. The model of hemolytic anemia was reproduced on 60 rats. Infusion drug "Reomannisol" and comparison drug "Reosorbilact" were administered in a dose of 10 ml/kg of animal weight the next day after the administration of phenylhydrazine for 5 days. The studies were performed in 1 - 2 - 5 days after the drug administration. Demonstrated decrease of endogenous intoxication markers when using "Reomannissol" indicated its efficacy.
Keyword: "Reomannisol", experimental hemolytic anemia, phenylhydrazine, endogenous intoxication.
DOI: https://doi.org/10.31838/ijpr/2019.11.03.113
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