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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Analysis of the association of polymorphism rs 4646421 of cytochrome gene P450 1A1 (CYP1A1) with formation and clinical course of acne in Uzbekistan.

Author: , MALIKOVA NILUFAR NUSRATULLAEVNA, KARIMOV KHAMID YAKUBOVICH, ARIFOV SAIDKASIM SAIDAZIMOVICH, BOBOEV KODIRJON TUHTABOEVICH
Abstract: The role of rs 4646421 polymorphism of the CYP1A1 gene (Cytochrome P450, family 1, member A1) in the development and clinical course of acne was analyzed. The study was carried out on samples of 165 patients with different clinical forms of acne and 161 conventionally healthy donors. Despite the significant contribution of CYP1A1 cytochrome enzyme level to the violation of sex hormone and vitamin A metabolism, the data obtained by us showed that there is no association of CYP1A1 gene polymorphism with acne development. The relative high prognostic efficacy of this locus as an independent marker of severe acne prognosis was revealed. The chance of detection of an unfavorable allelic variant of this genetic marker among patients with severe acne increased significantly in more than 2.1 times in comparison with the control group (?2=6.8; P=0.01; OR=2.1; 95%CI1.186- 3.56).
Keyword: Acne, cytochrome P450, polymorphism rs4646421, gene CYP1A1, allele, genotype
DOI: https://doi.org/10.31838/ijpr/2019.11.03.111
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