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Analysis of the association of polymorphism rs 4646421 of cytochrome gene P450 1A1 (CYP1A1) with formation and clinical course of acne in Uzbekistan.
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| Author:
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, MALIKOVA NILUFAR NUSRATULLAEVNA, KARIMOV KHAMID YAKUBOVICH, ARIFOV SAIDKASIM SAIDAZIMOVICH, BOBOEV KODIRJON TUHTABOEVICH
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| Abstract:
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The role of rs 4646421 polymorphism of the CYP1A1 gene (Cytochrome P450, family 1, member A1) in the
development and clinical course of acne was analyzed. The study was carried out on samples of 165 patients with
different clinical forms of acne and 161 conventionally healthy donors. Despite the significant contribution of
CYP1A1 cytochrome enzyme level to the violation of sex hormone and vitamin A metabolism, the data obtained
by us showed that there is no association of CYP1A1 gene polymorphism with acne development. The relative
high prognostic efficacy of this locus as an independent marker of severe acne prognosis was revealed. The chance
of detection of an unfavorable allelic variant of this genetic marker among patients with severe acne increased
significantly in more than 2.1 times in comparison with the control group (?2=6.8; P=0.01; OR=2.1; 95%CI1.186-
3.56).
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| Keyword:
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Acne, cytochrome P450, polymorphism rs4646421, gene CYP1A1, allele, genotype
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.03.111
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| Download:
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