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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis of O-[2-(1H-1,2,4-triazol-1- yl)ethyl]phenylthiocarbamate and O-[2-(1Himidazol- 1-yl)ethyl]phenylthiocarbamate with fungicidal activity

Author: , V.S. TALISMANOV, S.V. POPKOV, A.L. ALEKSEENKO, S.S. ZYKOVA, O.G. KARMANOVA
Abstract: The reaction of 1,2,4-triazole or imidazole with ethylene carbonate yielded 2-(1H-1,2,4-triazol-1-yl)ethanol and 2-(1H-imidazol-1-yl)ethanol, the interaction of which with phenylisothiocyanate in triethylamine synthesized O- [2-(1H-1,2,4-triazol-1-yl)ethyl]phenylthiocarbamate and O-[2-(1H-imidazol-1-yl)ethyl]phenylthiocarbamate, which in tests for fungicidal activity showed comparable activity with the reference substance – triadimefon.
Keyword: imidazole, fungicidal activity, thiocarbamate, 1,2,4-triazole.
DOI: https://doi.org/10.31838/ijpr/2019.11.03.096
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