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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Distribution of genotype and allele frequencies of polymorphism C634G of VEGF-A gene in patients with diabetic retinopathy

Author: , YUSUPOV AZAMAT FARKHADOVICH, KARIMOVA MUYASSAR KHAMITOVNA, ABDULLAEVA SAIDA IBRAGIMOVNA, BOBOEV KODIRJON TUKHTABAEVICH
Abstract: Aim: To study the polymorphism of C634G gene of VEGF-A in patients with nonproliferative diabetic retinopathy. Material and research methods: The study included 40 patients with type 2 diabetes mellitus (17 men and 23 women), 48 to 70 years old (mean age - 51±2.92 years old), with NPDR, and 50 healthy individuals (mean age - 31.2+0.5 years old). All patients with diabetes mellitus and 50 healthy donors of Uzbek nationality, who made up the control group, underwent PCR genotyping of polymorphism C634G of VEGF-A gene. Results: The obtained results on polymorphism of C634G gene of VEGF-A demonstrated a high frequency of occurrence of the mutant allele G among DR patients in comparison with the control group. Conclusions: As a result of the study of the polymorphic locus C634G of the VEGF-A gene, pronounced differences between a group of patients and healthy individuals in the Uzbek population were found. In the presence of the unfavorable G allele, the risk of diabetic retinopathy development increases by more than 2.1 times.
Keyword: Nonproliferative diabetic retinopathy, polymorphism, C634G gene VEGF A, mutant allele G.
DOI: https://doi.org/10.31838/ijpr/2019.11.03.082
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0.12
2018CiteScore
 
8th percentile
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