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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Studying the rheological properties of gel with regeneration action

Author: , KHAMDAMOV MIRZABOTIR MIRZAKHAYDAROVICH, ALIMDZHANOV IBROKHIM INOMOVICH, KARIEVA EKUT SAIDKARIMOVNA
Abstract: Purpose: Scientifically based approach to the selection of the type and concentration of the polymer in the development of the composition of the regenerating gel based on the study of the rheological characteristics of 4 samples of gels, the ascertainment of optimal conditions for its storage. Methods: The rheological parameters of the analyzed samples of the gel were studied using the “Reotest-2” rotational viscometer using a cell consisting of a system of coaxial cylinders S/S1 with a constant Z = 0.58, during the studies three temperatures were used - 250?, 400?, 550?. Results: An increase in the ultimate shear stress and a decrease in the effective viscosity under the influence of increasing deformation forces, which is a confirmation of the structure presence in the studied gel samples, has been ascertained. Evaluation of hysteresis loops of 4 samples suggests that reversible thixotropic bonds dominate in the analyzed samples, which can be restored after the destruction of the system. The maximum width of hysteresis loops was observed when using as a gelling agent - carbomer at a concentration of 1.5%, which served as a substantiation for choosing this polymer as the optimal one when selecting the composition of the dexpanthenol gel. Further studies carried out for the selected gel sample showed an inversely proportional dependence of the effective viscosity on the shear rate at various temperature conditions. The maximum width of the hysteresis loops, and respectively, the manifestation of the thixotropic properties of the gel on a 1.5% carbopol is observed at a temperature of 250C. The value of mechanical stability 2.43 confirms the high thixotropic properties of the proposed dexpanthenol gel, and the values of dynamic flow coefficients equal to Kd1 = 34.92%; Kd2 = 72.36% indicate a satisfactory degree of distribution of the gel when applied to the skin and mucous membranes, as well as during preparation. Conclusions: In the course of the research, the use of carbopol at a concentration of 1.5% was scientifically substantiated when developing the regenerating gel technology. The study of the rheological parameters of this sample depending on the temperature mode made it possible to predict a storage temperature not exceeding 250C. The results of studying the dynamic viscosity and dynamic flow coefficients confirm the high tixotropic properties and satisfactory degree of gel distribution during application and preparation.
Keyword: dexpanthenol, carbopol
DOI: https://doi.org/10.31838/ijpr/2019.11.03.090
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0.12
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