IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
RMDL: Classification of Parkinson's disease by nature-inspired Algorithm
Antidiabetic activity (In vitro alpha amylase inhibitory) of ethanol extract of Carissa carandas Linn. roots.
Six sigma: an embellished exploration in the field of pharmaceutical industry
The effect of Sida acuta on bacterial enzymes in azoxymethane-induced experimental colon cancer
Premature ageing in children: a rare genetic disorder called progeria.
Stress, Depression & Gut Microbiota: The Gut-Brain Axis Regulation
Zinc oxide nanoparticles and antibiotics mediated combinatorial approach to enhance antibacterial potential
Quality of life and associated factors among students in Jambi Province, Indonesia
Novel method for simultaneous determination of spiramycin and metronidazole in pharmaceutical dosage form by UV-visible absorption spectrophotometry
The Influence of Physicians Social Capital on Patients Satisfaction
1234
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Development and in-vivo evaluation of dry powders for reconstitution of solubility enhanced derivative of azithromycin dihydrate

Author: SRAVYA MADDUKURI, RADHA GV
Abstract: The objective of this work was to formulate an antibiotic dry syrup, which would show improved physical and chemical stability during its intended shelf life. Antibiotic azithromycin dihydrate, used to treat bacterial infections, is not soluble and stable in water. Hence, pediatric oral powders for suspensions are available which are merely stable only for 5 days after reconstitution. Solubility of azithromycin dihydrate was first improved by solid dispersions, inclusion complexation and nanosuspensions and then used the same in dry syrups. By this, solubility, stability could be improved, and taste masking could be achieved. Solubility enhancement was carried out through use of poloxamer 188, poloxamer 407 and polyethylene glycol 20,000 as carriers in two different concentrations and two methods- solvent evaporation and freeze drying. Similarly, Inclusion complexation using ß-cyclodextrin, epichlorohydrin- ß-cyclodextrin and sulfobutyl ether cyclodextrin was attempted using solvent evaporation and freeze drying. Nanosuspensions were also prepared using poloxamers and PVP, by nanoprecipitation technique and nanoprecipitation with cryoprotectants. All the solid dispersions, inclusion complexes and nanosuspensions were characterised using In-Vitro dissolution profiles, kinetic modelling, X ray diffractometry and SEM images. In vitro dissolution profile data suggested a significant improvement in drug release with inclusion complexes using sulfobutyl ether cyclodextrin, prepared by freeze drying and nanosuspensions using poloxamer 188, prepared by nanoprecipitation with cryoprotectants. X ray diffractograms showed a reduction in crystallinity. Kinetic modelling suggested a zero-order release mechanism. Hence, 2 inclusion complexes and 2 nanosuspensions were used to formulate dry syrups using Viscarin ph 209 and Gelcarin ph 812 as suspending agents. Powdered dry syrups were evaluated before reconstitution for their flow properties, and results showed excellent flow properties. Post reconstitution evaluation results also suggested a stable, flocculated oral suspension with sedimentation volume closer to 1 over tested period.
Keyword: Dry syrups, Reconstituted Suspensions, Inclusion complexation, Nanoparticles, Poloxamer.
DOI: https://doi.org/10.31838/ijpr/2019.11.03.069
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free