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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The Efficacy of 308-nm Monochromatic Excimer light and 0.1% Topical Tacrolimus in the treatment of Vitiligo

Author: , SHOKHAN ALI ABDULLAH*, MOHAMMED YOUSIF SAEED
Abstract: Background and objectives: Vitiligo is an acquired chronic skin disease characterized by circumscribed depigmented macules and patches. Our aim is to evaluate the efficacy of combined therapy of 308-nm Monochromatic Excimer light (MEL) with 0.1% topical tacrolimus, versus 308-nm MEL alone in treating vitiligo. Methods: In this study thirty patients, with Fitzpatrick skin types III to IV, aged 12 to 57 years were recruited to take part. Eighty symmetrical vitiliginous patches at different body sites were selected and divided equally into two groups A and B. Each group treated with 308-nm MEL twice weekly for total of 30 sessions. Topical tacrolimus 0.1% added concurrently to group A and applied twice daily on a targeted lesion throughout the study. Results: Lesions located on face and trunk in group A 9.31% achieved complete repigmentation versus 47.8% in group B. Lesions located on extremities and acral area in group A 47.1% were achieved 50 – 74% repigmentation, whereas in group B 11.8% of lesions achieved 50-74% repigmentation. Furthermore, in group A, 5 patches (29.4%) in acral area were unresponsive to treatment, versus 8 patches (47.1%) in group B were lacking response to the treatment. Conclusion: The outcome of this study concluded that combined therapy of 308-nm MEL with a topical tacrolimus 0.1% is more preferable to MEL alone in treatment of vitiligo, especially in lesion’s localized in UV sensitive area (face and trunk). Moreover, the combination therapy remains superior to monotherapy in more resistant anatomical sites (Acral and bony prominence).
Keyword: 308-nm; combination; monochromatic; excimer; vitiligo; tacrolimus.
DOI: https://doi.org/10.31838/ijpr/2019.11.02.106
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