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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation of extended release valsartan tablets using pharmaceutical gum as matrixing agent and optimisation by applying 32 (three squire) full factorial design

Author: SUBHRANSHU PANDA, NISHITH PATEL, SIVA PRASAD PANDA, CH. SURYA KUMARI
Abstract: The aim of this study was to explore the scope of pharmaceutical gum- “Pharmagum® M, to control the drug releases and to establish the influence of various excipients used in tablet formulations. Valsartan was chosen for incorporation in matrix tablet and to develop extended release preparation, for treatment of heart failure and post myocardial infarction patients. The various excipients viz. Microcrystalline cellulose, Colloidal Silicon dioxide, Lactose, Sodium starch glycolate (SSG) and Silica gel H were tried to check their action on drug release. A 32 full factorial design was selected to optimize the formulation and the amount of superdisintigrant, Sodium starch glycolate (SSG) (X1) and Silica gel H (X2) were selected as independent variables. The response (Yi) as percentage drug releases at 4 h and 8 h was measured for each trial and statistical equations with significant interaction terms were derived to predict Y4 and Y8. Checkpoint batches were prepared to prove the validity of the evolved mathematical equations. The drug release mechanism was predominantly found to be Fickian diffusion controlled.
Keyword: Pharmagum® M; Valsartan, Matrix tablet; Factorial design; Fickian diffusion controlled.
DOI: https://doi.org/10.31838/ijpr/2019.11.03.018
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