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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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EFFICACY OF EMBLICA OFFICINALIS ON SERUM ENZYMES AGAINST AIR POLLUTANTS EXPOSED ALBINO RATS.

Author: DR. YADAV, ASHA AGARWAL, PREETI KUMARI, VISHNU SHARMA
Abstract: Environmental pollution, a major problem for developed and developing countries. The adverse role of air pollution on environment and ecosystem cannot be denied. The present investigation is designed to evaluate alterations in serum enzymes which includes ALP, AST, ALT and GGT after SO2 and NO2 exposure in adult albino rats. The rats were randomly divided into seven sets, set-A served as control exposed to ambient air, set-B and set-C received whole body exposure of 80 ppm of SO2 and NO2, respectively for 30 and 60 days, while set-D received whole body exposure of combination of SO2 and NO2 for 30 and 60 days and set-E, F and G received 80 ppm of SO2, 80 ppm NO2 and combination of SO2 and NO2 along with 200 mg/kg b.wt. Emblica officinalis for 30 and 60 days, respectively. Result of the present study shows significant(at p< 0.01) alterations in ALP, AST, ALT and GGT after exposure to SO2 and NO2 gas respectively, while highly significant (at p<0.001) after combination of SO2 and NO2 exposure in comparison to control rats. The oral administration of Emblica officinalis neutralizes adverse effects induced by the aforesaid air pollutants.
Keyword: albino rat, SO2, NO2, Emblica officinalis and Serum enzymes
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