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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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CLINICAL AND IMMUNOLOGICAL EFFICIENCY "IMUNOFAN" IN THE TREATMENT OF NUMMULAR MICROBIAL ECZEMA

Author: Z.R. KHISMATULLINA, N.A. NADYRCHENKO
Abstract: Nummular microbial eczema is characterized by a severe, often relapsing course with resistance to standard therapies, which leads to an increase in cases of temporary disability and the need for hospitalization of patients. The aim of the study was to evaluate the clinical and immunological effectiveness of the immunomodulator Imunofan in the treatment of moderate nummular microbial eczema to substantiate its practical application. 80 patients, among them 50 women (62.5%) and 30 men (37.5%) aged from 35 to 56 years old were included in the main group, where complex therapy was applied. The control group, where standard therapy was applied, included 104 patients, among them 62 women (59.6%) and 42 men (40.4%) aged 35 to 56 years. The group of healthy donors included 50 people: 32 women (64%) and 18 men (46%) aged 35 to 55 years. Evaluation of the clinical efficacy of the treatment was carried out using the index of severity of microbial eczema and the dermatological quality of life index, the quantitative determination of TNF-a in serum was performed by enzyme immunoassay. The results of the study showed that the use of the immunomodulator Imunofan in the complex therapy of patients with moderately severe nummular microbial eczema reduced the activity of the inflammatory process in the skin by reducing the amount of TNF-a in the blood serum, obtaining a positive dynamic of the clinical picture, reducing the risk of recurrence and reduce the time of hospitalization.
Keyword: nummular microbial eczema, imunofan, TNF-a, index of severity of microbial eczema, dermatological index of quality of life.
DOI: https://doi.org/10.31838/ijpr/2019.11.03.068
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