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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The protective effect of the N-acetylcysteine on acute liver toxicity induced by carboplatin in rat model

Author: EKHLAS HASSAN,, SAHAR ABDULRUDHA MAJEED, AMMAR RASOUL MOHAMMAD, KARRAR KAREEM GAEN
Abstract: Carboplatin is a second generation platinum chemotherapeutic agent. Hepatotoxicity is a major dose regulating-factor while high dose platinum chemotherapy has been continued. Aim of this study is to test the hepatoprotective effect of the N-acetylcysteine (NAC) on acute liver toxicity induced by carboplatin in rat model. 24male and female sexually mature Sprague-Dawley rats were encompassed in this study, randomly divided into 4 groups, each one included 6 rats. group 1 received saline & considered as control group, group 2 received NAC, group 3 received carboplatin & group 4 received carboplatin + NAC for five days . After treatment, blood samples were collected from animals for measuring of serum total bilirubin, AST, ALT & LDH then animals were killed & dissected. Liver tissue of rats in all groups were examined for histopathological changes . carboplatin cause significant elevation in total bilirubin, AST, ALT & LDH (p< 0.001)with marked histopathological changes in liver suggesting carboplatin- induced hepatotoxicity. Group of rats treated with carboplatin & NAC had significant reduction in total bilirubin, AST, ALT & LDH (p< 0.001) with slight histopathological changes in liver suggesting protective effect for NAC against carboplatin- induced hepatotoxicity. NAC could be had protective effect on carboplatin- induced hepatotoxicity.
Keyword: carboplatin, liver toxicity, N-acetylcysteine .
DOI: https://doi.org/10.31838/ijpr/2019.11.03.057
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