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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Atorvastatin loading before percutaneous coronary intervention down-regulates Toll-like receptor4 expression and ameliorates myocardial injury markers

Author: NAJAH HADI, SAHAR A. MAJEED, KHALID I. AMBER, GHIZAL FATIMA, AHMED N REGEEB, NASSER GHALY YOUSIF, RAM SINGH
Abstract: The aim of the study was to assess the activity of pre-PCI atorvastatin reload on the acute inflammatory responses and in Toll-Like Receptor 4 expressions with its downstream signaling. A double-blind randomized prospective study, 30 patients who received low dose atorvastatin 40 mg/day without reload. While, 30 patients who were already on the usual dose of atorvastatin with further 80 mg & 40 mg at 12 and 2 hrs before PCI respectively. TLR4 expression in peripheral monocyte investigate by flow cytometry, and cardiac troponin I, CK-MB, HsCRP and HMG-BOX protein by ELISA technique immediately before and at 4 hrs, 12 hrs. After PCI. Stent implantation was associated with an elevation in TLR 4 expression in peripheral monocyte of both study groups after stenting with higher expression level was found among control group (p<0.05) at 4 hr and 12 hr post-PCI. HsCRP, HMGbox1protein were lower in atorvastatin reload group (p<0.05), and the myocardial injury markers (CKMB, troponin I) were significantly higher among the control group than atorvastatin reload group (p<0.05). Atorvastatin attenuated toll-like receptor 4 expressions on peripheral monocyte subsequently its downstream effects HsCRP and HMGBOX1-protein.
Keyword: Toll-like receptor2, Atorvastatinre, Percutaneous coronary intervention, myocardial injury markers
DOI: https://doi.org/10.31838/ijpr/2019.11.03.056
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