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Phytochemical screening, antioxidant and cytotoxic activities of M. vulgare
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| Author:
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IMAD KABACH, REDA BEN MRID, NAJAT BOUCHMAA, YOUSSEF BOUARGALNE, ABDELMAJID ZYAD, MOHAMED NHIRI
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| Abstract:
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Phytochemicals are extensively found at different levels in many medicinal plants. For that,in this study, the extracts of
Marrubiumvulgare L were studied for antioxidant and polyphenols contents as well as cytotoxicity activities.The antioxidative
activities were determined using four methods: free radical scavenging assays (DPPH• and ABTS•+ tests),
ferrous ions (Fe2+) chelating activity and reducing power assay (FRAP). Additionally, total flavonoids and phenolic
contents were also determined. For all tests performed, methanolic extracts exhibited a strong antioxidant activity.
The cytotoxic activity was assessed on two different breast cancer cell lines (MDA-MB-468 and MCF-7), using MTT
assay. The results obtained shows the methanolic extract possesses moderate anti-proliferative activity against two
human breast cancer cells lines.
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| Keyword:
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Marrubiumvulgare L., phenolic content, antioxidant,cytotoxicity.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.03.055
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| Download:
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