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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Phytochemical screening, antioxidant and cytotoxic activities of M. vulgare

Author: IMAD KABACH, REDA BEN MRID, NAJAT BOUCHMAA, YOUSSEF BOUARGALNE, ABDELMAJID ZYAD, MOHAMED NHIRI
Abstract: Phytochemicals are extensively found at different levels in many medicinal plants. For that,in this study, the extracts of Marrubiumvulgare L were studied for antioxidant and polyphenols contents as well as cytotoxicity activities.The antioxidative activities were determined using four methods: free radical scavenging assays (DPPH• and ABTS•+ tests), ferrous ions (Fe2+) chelating activity and reducing power assay (FRAP). Additionally, total flavonoids and phenolic contents were also determined. For all tests performed, methanolic extracts exhibited a strong antioxidant activity. The cytotoxic activity was assessed on two different breast cancer cell lines (MDA-MB-468 and MCF-7), using MTT assay. The results obtained shows the methanolic extract possesses moderate anti-proliferative activity against two human breast cancer cells lines.
Keyword: Marrubiumvulgare L., phenolic content, antioxidant,cytotoxicity.
DOI: https://doi.org/10.31838/ijpr/2019.11.03.055
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0.12
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