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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Preparation, Characterization and Study Pathogenic Bacteria of Derivatives of Pyrimidine

Author: HIYAMHAITHAM MOHAMMED ALI , RAGHADABDULATIFABDULRAZAQ
Abstract: This study includes synthesis and characterization of derivatives of pyrimidines (R or Ar-2,3,4,6,7,8- hexahydroquinazolin-5(1H)-one), via of the reaction from aldehyde derivatives with cyclohexane-1,3-dione and guanidine hydro chlorid. This mixture was refluxed for (4 – 6) hrs; while maintaining the pH at 6. Using absolute ethanol as a solvent. The prepared compounds were characterized by melting point, FT-IR , UV-Vis 1H-NMR and 13CNMR spectroscopy . Some derivatives of pyrimidinetestad pathogenic bacterial isolates that included gram positive bacteria Staphylococcus aureasand gram negative bacteria Pseudomonas aeruginosawere obtained from Department of Biology/ college of Sciences / Al-Mustansiriyah University,
Keyword: Preparation , Characterization , Pyrimidines , Staphylococcus aureas
DOI: https://doi.org/10.31838/ijpr/2019.11.03.048
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