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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Soluble Intercellular Adhesion molecule-1 and its correlation with some inflammatory markers in Hemodialysis patients

Author: SAHLAHKH. ABBAS
Abstract: In hemodialysis (HD) patients, the serum level of sICAM-1 and C-reactive protein (CRP) changes, which considers as risk factors for cardiovascular events and mortality in these patients. Some hematological, biochemical and soluble form of intercellular adhesion molecule-1, CRP levels were evaluated in 63 dialysis patients attended general Kirkuk Hospital for dialysis, compared to 20healthy control subject, during the period between July 2018 to December 2018.. Both soluble form of ICAM-1 and CRP were elevated significantly (p<0.001) in HD patients compared to control group. Also there were a significant increased in the serum levels of Urea and Creatinine (p<0.001), in addition to Lymphocyte and monocyte counts(p<0.01) compared to control group. In contrast there were a significant decrease in Hemoglobin(Hb) concentration and High density lipoprotein(HDL). serum level of ICAM-1 correlated significantly with Total leukocyte. Elevated serum level of ICAM-1 in HD patients, this may be due to its enhanced synthesis and release during dialysis. Increased serum level of ICAM-1 and CRP with decreased levels of HDL and Lymphocyte considers as risk factors for cardiovascular complication . The results revealed a significant positive correlation between ICAM-1 and Total leukocyte, this may lead to the pathogenesis of atherosclerosis in HD patients. Suggesting an important role of dialysis in chronic renal failure.
Keyword: Hemodialysis, Intercellular adhesion molecule-1, C-reactive protein.
DOI: https://doi.org/10.31838/ijpr/2019.11.03.043
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