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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis and Characterization of new Schiff base of Cefadroxil and study their antibacterial activity

Author: ZIAD I., MUAYED AHMED REDAYAN, MOSTEFE KHALIDMOHAMMED
Abstract: In this study a new imine derived from cefadroxil and some aldehydes were prepared, characterized and biologically screened. An amino group available in the cefadroxil was treated with, 4-Hydroxybenzaldehyde, Benzaldehyde, Salicylaldehyde, 2-Hydroxynaphtalaldehyde,2-Thiophenecarboxaldehyde, Acetaldehyde and 2-Thiophenealdehyde to obtain Schiff base. The biological activity was tested for the new compounds and show good activities in comparison to starting material. All synthesized compounds were scanned for their antibacterial activity toward gram-ve (A.baumannii and P.aeruginosa) and gram +ve(S.aureusand B.Subtilis) bacteria, the synthesized derivatives gave good to moderate activity toward both mentioned types of bacteria.
Keyword: Schiff base, Synthesis, Antibiotic, 2-thiophenealdehyde,Cefadroxil
DOI: https://doi.org/10.31838/ijpr/2019.11.03.041
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0.12
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