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Synthesis and Characterization of new Schiff base of Cefadroxil and study their antibacterial activity
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| Author:
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ZIAD I., MUAYED AHMED REDAYAN, MOSTEFE KHALIDMOHAMMED
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| Abstract:
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In this study a new imine derived from cefadroxil and some aldehydes were prepared, characterized and biologically
screened. An amino group available in the cefadroxil was treated with, 4-Hydroxybenzaldehyde, Benzaldehyde,
Salicylaldehyde, 2-Hydroxynaphtalaldehyde,2-Thiophenecarboxaldehyde, Acetaldehyde and 2-Thiophenealdehyde to
obtain Schiff base. The biological activity was tested for the new compounds and show good activities in comparison
to starting material. All synthesized compounds were scanned for their antibacterial activity toward gram-ve
(A.baumannii and P.aeruginosa) and gram +ve(S.aureusand B.Subtilis) bacteria, the synthesized derivatives gave good
to moderate activity toward both mentioned types of bacteria.
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| Keyword:
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Schiff base, Synthesis, Antibiotic, 2-thiophenealdehyde,Cefadroxil
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.03.041
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| Download:
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Request For Article
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