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Synthesis, Characterization,and Antibacterial Screening of Some New Benzimidazole Derivatives Having1,3,4- Thiadiazole Ring
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| Author:
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MUHANNED MAHMOUD, MUAYED AHMED REDAYAN, WASANABDULRAZZAQMAHMOOD
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| Abstract:
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various novel benzimidazole derivatives linked to 1,3,4-thiadiazole carrying imine group were synthesized using
nucleophilic substitution reaction between 2-mercapto-1H-benzimidazole (1) with5-(chloromethyl)-1,3,4-thiadiazol-2-
amine (2) to produce compound 3, which then condensation with various aromatic aldehydes to yielded Schiff bases
compounds 4(a-d). The structure of all the compounds which have been synthesized was characterized by IR and
some of them by 1H-NMR). The preparation compounds4(a-d) have been screened their antibacterial activities against
bacteria like: E.coli and p. aeruginosaas v- bacteria and S. aureus and B. subtilisas v+ bacteria which several of these
synthesized compoundsdisplayperfectantibacterial activity.
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| Keyword:
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benzimidazole ,1,3,4-thiadiazole ,Schiff base , antibacterial activity .
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.03.040
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| Download:
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