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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis, Characterization,and Antibacterial Screening of Some New Benzimidazole Derivatives Having1,3,4- Thiadiazole Ring

Author: MUHANNED MAHMOUD, MUAYED AHMED REDAYAN, WASANABDULRAZZAQMAHMOOD
Abstract: various novel benzimidazole derivatives linked to 1,3,4-thiadiazole carrying imine group were synthesized using nucleophilic substitution reaction between 2-mercapto-1H-benzimidazole (1) with5-(chloromethyl)-1,3,4-thiadiazol-2- amine (2) to produce compound 3, which then condensation with various aromatic aldehydes to yielded Schiff bases compounds 4(a-d). The structure of all the compounds which have been synthesized was characterized by IR and some of them by 1H-NMR). The preparation compounds4(a-d) have been screened their antibacterial activities against bacteria like: E.coli and p. aeruginosaas v- bacteria and S. aureus and B. subtilisas v+ bacteria which several of these synthesized compoundsdisplayperfectantibacterial activity.
Keyword: benzimidazole ,1,3,4-thiadiazole ,Schiff base , antibacterial activity .
DOI: https://doi.org/10.31838/ijpr/2019.11.03.040
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