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Comparison Between effect of Silymarin Extract and Legalon70 in Cyclosporine A-Induced Toxicity in Rats
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| Author:
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SAMERA ALKATIB
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| Abstract:
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Silymarin is the active constituent of milk thistle seeds consist of four flavonolignan isomers with antioxidant and
protection features on hepatocytes against damage. Currently, the commercial silymarin preparations are available
and used in the alternative medicine for liver diseases. The aim of this study was to compared the effect of silymarin
extracted from milk thistle seeds with commercial one (Legalon 70) in blood and tissues against cyclosporine A–
induced toxicity in rats. Twenty-four albino male rats of 3 months age were divided into four groups: Group (1)
control, maintain on control diet. Group2 (CsA) treated with 20mg/Kg subcutaneous injection of cyclosporine A.
Group3 (CsA + siL) treated with 20mg/Kg CsA and 5mg single oral dose of silymarin daily. Group 4 (CsA + Leg)
treated with 20 mg/Kg CsA and 5mg single oral dose of Legalon 70daily. After 3 weeks of the treatment, rats were
sacrificed and the serum, Liver, and kidney tissues were collected for analysis. CsA-toxicity was evaluated by
decreased serum total protein, albumin, and HDL levels and increased serum alanine aminotransferase (ALT),
aspartate aminotransferase (AST), bilirubin, creatinine, total cholesterol, triglycerides, and LDL levels. In liver and
kidney, toxicity was assessed by reducing total protein and GsH and increasing MDA concentrations. Both silymarin
extract and Legalon 70 showed a close effects in improving liver and kidney functions, and significantly recovery the
blood and tissues parameters to approximately normal levels. None of the blood or tissues parameters differed
significantly in (CsA + SIL) or (CsA + Leg) group. This study indicated that is a possibility to use the silymarin extract
for liver patients as an alternative medicine and dispense with the commercial preparations.
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| Keyword:
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(CsA + siL),Group2,bilirubin, creatinine.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.03.039
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| Download:
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