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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Comparison Between effect of Silymarin Extract and Legalon70 in Cyclosporine A-Induced Toxicity in Rats

Author: SAMERA ALKATIB
Abstract: Silymarin is the active constituent of milk thistle seeds consist of four flavonolignan isomers with antioxidant and protection features on hepatocytes against damage. Currently, the commercial silymarin preparations are available and used in the alternative medicine for liver diseases. The aim of this study was to compared the effect of silymarin extracted from milk thistle seeds with commercial one (Legalon 70) in blood and tissues against cyclosporine A– induced toxicity in rats. Twenty-four albino male rats of 3 months age were divided into four groups: Group (1) control, maintain on control diet. Group2 (CsA) treated with 20mg/Kg subcutaneous injection of cyclosporine A. Group3 (CsA + siL) treated with 20mg/Kg CsA and 5mg single oral dose of silymarin daily. Group 4 (CsA + Leg) treated with 20 mg/Kg CsA and 5mg single oral dose of Legalon 70daily. After 3 weeks of the treatment, rats were sacrificed and the serum, Liver, and kidney tissues were collected for analysis. CsA-toxicity was evaluated by decreased serum total protein, albumin, and HDL levels and increased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, creatinine, total cholesterol, triglycerides, and LDL levels. In liver and kidney, toxicity was assessed by reducing total protein and GsH and increasing MDA concentrations. Both silymarin extract and Legalon 70 showed a close effects in improving liver and kidney functions, and significantly recovery the blood and tissues parameters to approximately normal levels. None of the blood or tissues parameters differed significantly in (CsA + SIL) or (CsA + Leg) group. This study indicated that is a possibility to use the silymarin extract for liver patients as an alternative medicine and dispense with the commercial preparations.
Keyword: (CsA + siL),Group2,bilirubin, creatinine.
DOI: https://doi.org/10.31838/ijpr/2019.11.03.039
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