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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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PREPARATION AND IN-VITRO EVALUATION OF IMPLANTABLE FILM CONTAINING MICROENCAPSULATED SUSTAINED RELEASE DEXAMETHASONE SODIUM PHOSPHATE

Author: MOHAMMED ABDUL, NIDHAL K. MARAIE
Abstract: This work involved the preparation, optimization and in vitro evaluation of the release of the model drug dexamethasone sodium phosphate from implantable film dosage form containing microencapsulated dexamethasone sodium phosphate to be inserted at the inflamed areas to get suitable precise controlled release. Our previously prepared sustain release dexamethasone sodium phosphate microcapsules containing 17.6 mg dexamethasone sodium phosphate (which is equivalent to 16 mg dexamethasone) and using poly(lactic-co-glycolic acid) (PLGA) as a coating material was used to prepare thin film by inserting it in a Poly(vinyl alcohol) (PVA) / glycerol base to which 4.4 mg pure dexamethasone sodium phosphate (which is equivalent to 4 mg dexamethasone) was add, then casting technique was applied to get a thin film (2 cm x 0.2 cm). The obtained film was dried and subjected to in-vitro evaluation like uniformity of weight, thickness and surface pH, folding endurance, integrity during measuring percentage moisture absorption (PMA) and percentage moisture loss (PML) and the in vitro drug release. The prepared implantable film showed less than 5% in weight variation with a weights range from 158 to 164, acceptable thickness (average between 1.09 to 2.05) and surface pH ( between 7 to 7.32), good folding endurance which is more than 300 times, and good integrity during measuring percentage moisture absorption (PMA) and percentage moisture loss (PML). The in vitro drug release (using a modified Franz diffusion cell) showed biphasic drug release where 22.05% of the total amount of DSP in the film was released within 6 hrs and the release continued for 5 months in which 86.18% of the total incorporated DSP was released after 5 months. this work succeeded in preparing optimized implantable film containing microencapsulated dexamethasone sodium phosphate which gave biphasic drug release pattern that can be successfully inserted at their inflamed area (such as during joint replacement surgery and other operation) to give precise controlled release which can be used as alternative to conventional treatment regimen for dexamethasone which involves multi-dose ( injectable and oral) that subject the patient to many undesirable effects and affect patient compliance.
Keyword: microencapsulated, dexamethasone sodium phosphate, solvent evaporation technique, entrapment efficacy, % yield.
DOI: https://doi.org/10.31838/ijpr/2019.11.03.037
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