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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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INCIDENCE AND ASSOCIATED FACTORS OF ADVERSE DRUG REACTIONS IN GENERAL MEDICINE DEPARTMENT OF A TERTIARY CARE TEACHING HOSPITAL

Author: RACHANA J, C.S. SHASTRY, UDAY VENKAT MATETI, RAGHAV SHARMA, NANDAKUMAR UP, SHARAD CHAND
Abstract: Adverse drug reactions (ADRs) are one of the major causes of morbidity and mortality. To assess the incidence and cost involved in ADRs reported in the general medicine department. A prospective observational study was carried out for a period of 8 months from August 2016 to March 2017. Patients enrolled as per the study criteria then ADRs data was evaluated by assessment of causality, severity, and preventability. The cost incurred for the management of ADRs was calculated. From a total number of 240 patients, 127 (52.91%) were males and 113 (47.08%) were females. The causality assessment by Naranjo’s scale showed that the majority of the reactions was probable 32 (72.7%), followed by possible 12 (27.3%). Based on WHO-UMC Scale, 36 (81.8%) were probable, followed by 8(18.2%) possible reactions. Majority of the reactions, 29 (66%) were moderate in severity. About 42 (95.5%) reactions were probably preventable, and 2 (4.5%) were preventable. Total cost for the management of ADRs was INR 173673.00. The study concludes that regular monitoring of ADRs may be required to reduce the morbidity and to improve patient compliance, which in turn can produce a better therapeutic outcome.
Keyword: Adverse Drug Reaction, Causality Assessment, Incidence, General Medicine
DOI: https://doi.org/10.31838/ijpr/2019.11.03.027
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