IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
Prevalence and Risk Factors of Occupation Induced Asthma among Traffic Police in Bangalore City
o Estimate the Prevalence of Depression, Anxiety, and Stress among Adolescents in Kancheepuram District, Tamil Nadu
A Study on Risk Factors of Anaemia among Pregnant Women
n Approach of Nutritional Deficiency Disorder among Pregnant Women
The Determinants of Self Care Practices By Using DSME to Facilitate the Patients In Kanchipuram District
An evaluation of Epidemiological Factors Relating to Overweight, Obesity in Urban Chennai
A study on the Pattern of Body Image Perception among Adolescents in Urban Chennai
mpact of an External and Internal factors of overweight and obesity in urban
A study on Anti-Rabies Vaccine among Dog Bite Victims in chennai region
Hospital Based Cross Sectional Study: Distribution of Compliance for completion of ARV 4 dose among study participants
12345678910...
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Study of Physicochemical Parameters of Mucoadhesive Microspheres for Metronidazole to Develop Sustained Release Dosage Form

Author: PRIYANKA BHATI, MALLIKARJUNA B.P, MOHSIN HASAN
Abstract: The objective of the present study was to study physicochemical properties of mucoadhesive microspheres of metronidazole to develop sustained release formulation for the treatment of periodontal diseases. The prepared microspheres would characterize to remains at affected area for longer duration pertaining to mucoadhesive property of formulation. We prepared mucoadhesive microspheres for metronidazole in six batches (i.e. F1-F6) using Xanthan gum (Xn) and Sodium CMC (Na-CMC) in different drug polymer ratios by adopting solvent evaporation method. The drug–polymer and excipient compatibility was determined by IR- spectrophotometric analysis and there was not any chemical or physical interaction observed between drug & polymer. All prepared formulations were subjected to evaluate physicochemical studies such as % yield, particle size, drug entrapment efficiency, surface morphology, mucoadhesive test, swelling index, in-vitro drug release, release kinetics and stability studies. The results analysis was found that the adopted method for the formulation of designed schemes was reproducible and easy to work on it. All the comparative results were found innovative and satisfactory. In-vitro release studies indicated that the metformin loaded mucoadhesive microspheres provided controlled drug release over a period of 12 hrs. The optimized batch no.-F6 showed percentage yield (87.95%), particle size (200.51µm), Entrapment efficiency (78.36 ± 0.028%), and swelling index (84.22%) with good mucoadhesive strength. Percent drug release in pH 6.8 phosphate buffer was found to be 90.936 ± 0.190%. So that the present studied revealed that the mucoadhesive microspheres using this particular method is useful and novice and also impetus to other researchers in designing this formulation using other drugs in improvising drug therapy for oral cavity.
Keyword: mucoadhesive microspahres, Xanthum gum, sodium CMC, Gum diseases etc.
DOI: https://doi.org/10.31838/ijpr/2019.11.03.024
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free
0.07
2017CiteScore
 
11th percentile
Powered by  Scopus