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Study of Physicochemical Parameters of Mucoadhesive Microspheres for Metronidazole to Develop Sustained Release Dosage Form
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| Author:
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PRIYANKA BHATI, MALLIKARJUNA B.P, MOHSIN HASAN
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| Abstract:
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The objective of the present study was to study physicochemical properties of mucoadhesive microspheres of
metronidazole to develop sustained release formulation for the treatment of periodontal diseases. The prepared
microspheres would characterize to remains at affected area for longer duration pertaining to mucoadhesive property
of formulation. We prepared mucoadhesive microspheres for metronidazole in six batches (i.e. F1-F6) using Xanthan
gum (Xn) and Sodium CMC (Na-CMC) in different drug polymer ratios by adopting solvent evaporation method. The
drug–polymer and excipient compatibility was determined by IR- spectrophotometric analysis and there was not any
chemical or physical interaction observed between drug & polymer. All prepared formulations were subjected to
evaluate physicochemical studies such as % yield, particle size, drug entrapment efficiency, surface morphology,
mucoadhesive test, swelling index, in-vitro drug release, release kinetics and stability studies. The results analysis was
found that the adopted method for the formulation of designed schemes was reproducible and easy to work on it. All
the comparative results were found innovative and satisfactory. In-vitro release studies indicated that the metformin
loaded mucoadhesive microspheres provided controlled drug release over a period of 12 hrs. The optimized batch
no.-F6 showed percentage yield (87.95%), particle size (200.51µm), Entrapment efficiency (78.36 ± 0.028%), and
swelling index (84.22%) with good mucoadhesive strength. Percent drug release in pH 6.8 phosphate buffer was found
to be 90.936 ± 0.190%. So that the present studied revealed that the mucoadhesive microspheres using this
particular method is useful and novice and also impetus to other researchers in designing this formulation using other
drugs in improvising drug therapy for oral cavity.
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| Keyword:
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mucoadhesive microspahres, Xanthum gum, sodium CMC, Gum diseases etc.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.03.024
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| Download:
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