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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Possible Roles of miRNAs-25 and 375 as Potent Biomarkers for ß-cellsStress and/or Death in DiabetesType 1 Patients and their First Degree Relatives

Author: , MADHA MOHAMMED SHEET, HASAN ABD ALI KHUDHAIR
Abstract: Diabetes Type 1 (T1D) is an autoimmune condition represent by pancreatic ß-cells loss due to autoimmune processes, which reflected by presence of autoantibodies directed against islets ß-cells auto-antigens. This study was aimed to identify the predictive power and the degree of correlation of genetic biomarkers (miRNA-25 and miRNA-375) on ß- cells stress and/or death in T1D individuals and their first degree relatives (FDRs). Three subjects of T1D individuals, FDRs and apparently healthy individuals were enrolled in this study and evaluated for their serum C-peptide and expression level of miRNA-25 and miRNA-375. The results showed that the frequency of normal level and mean titer of C-peptide were significantly low among T1D and their FDRs. The frequency of high level and mean titer of miRNA- 25 were significantly low in both groups. For miRNA-375, the results revealed low level in 35% of T1D patient and in 10% of FDRs, whereas the mean titer was significantly higher among FDRs in comparison to HC. The miRNA-25 level was significantly lower in subjects with below normal C-peptide than subjects with normal or above normal C-peptide. Furthermore, miRNA-25 level was statistically highest in individuals with low miRNA-375 level than those with high level. Finally, a significant elevationinmiRNA-375 level was noticed among the individuals with below normal C-peptide compared to individuals with normal or above normal level of C-peptide. In conclusion, miRNA-25 had expressed a decreased level among the new onset T1D patients and their FDR, whereas miRNA-375 had expressed decreased level among newly onset T1D and elevated level among FDRs. The correlation between the residual ß-cells mass and the miRNA-25 serum level was positive which indicate the possible utility of its low expression as a ß-cells stress and/or death predictive biomarker. On the other hand the correlation between the residual ß-cells mass and the miRNA-375 serum level was negative which indicate the possible utility of its high expression as a ß-cellsstress and/or death predictive biomarker.
Keyword: Diabetes Type 1, micro-RNAs and ß-cells stress/death
DOI: https://doi.org/10.31838/ijpr/2019.11.03.023
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