IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

ISSN
0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Formulation & Optimization of Microemulsion Based Transdermal Gel of Atomoxetine Hydrochloride

Author: DR. PRAJAPATI, MR. TULARAM BAROT
Abstract: The present investigation is aimed at developing Atomoxetine Hydrochloride based transdermal gel for systemic delivery of the medicament. Atomoxetine Hydrochloride is used for the treatment of the Attention Deficit Hyperactivity Disorder (ADHD) in children. For developing microemulsion based formulation, the solubility of drug was determined in different oils, surfactants & co-surfactants and it wa observed that Atomoxetine Hydrochloride showed its best solubility in Capmul MCM C8 EP, Cremophore RH 40 and PEG 400 respectively. The best Smix ratio was found to be 3:1. The microemulsion was optimized using mixture optimal design. The optimized formulation was evaluated for various evaluation parameters. The optimized microemulsion was incorporated in the gel base to obtain final dosage form. The drug release study of the final gel was performed ex-vivo using Franz diffusion cell using rat skin as a transdermal barrier.
Keyword: Atomoxetine Hydrochloride, Attention Deficit Hyperactivity Disorder, Transdermal, Microemulsion based gel
DOI: https://doi.org/10.31838/ijpr/2019.11.03.021
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0.12
2018CiteScore
 
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0.07
2017CiteScore
 
11th percentile
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477