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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation & Optimization of Microemulsion Based Transdermal Gel of Atomoxetine Hydrochloride

Author: BHUPENDRA PRAJAPATI, TULARAM BAROT
Abstract: The present investigation is aimed at developing Atomoxetine Hydrochloride based transdermal gel for systemic delivery of the medicament. Atomoxetine Hydrochloride is used for the treatment of the Attention Deficit Hyperactivity Disorder (ADHD) in children. For developing microemulsion based formulation, the solubility of drug was determined in different oils, surfactants & co-surfactants and it wa observed that Atomoxetine Hydrochloride showed its best solubility in Capmul MCM C8 EP, Cremophore RH 40 and PEG 400 respectively. The best Smix ratio was found to be 3:1. The microemulsion was optimized using mixture optimal design. The optimized formulation was evaluated for various evaluation parameters. The optimized microemulsion was incorporated in the gel base to obtain final dosage form. The drug release study of the final gel was performed ex-vivo using Franz diffusion cell using rat skin as a transdermal barrier.
Keyword: Atomoxetine Hydrochloride, Attention Deficit Hyperactivity Disorder, Transdermal, Microemulsion based gel
DOI: https://doi.org/10.31838/ijpr/2019.11.03.021
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