|
Formulation & Optimization of Microemulsion Based Transdermal Gel of Atomoxetine Hydrochloride
|
|
| Author:
|
BHUPENDRA PRAJAPATI, TULARAM BAROT
|
| Abstract:
|
The present investigation is aimed at developing Atomoxetine Hydrochloride based transdermal gel for systemic
delivery of the medicament. Atomoxetine Hydrochloride is used for the treatment of the Attention Deficit
Hyperactivity Disorder (ADHD) in children. For developing microemulsion based formulation, the solubility of drug
was determined in different oils, surfactants & co-surfactants and it wa observed that Atomoxetine Hydrochloride
showed its best solubility in Capmul MCM C8 EP, Cremophore RH 40 and PEG 400 respectively. The best Smix ratio
was found to be 3:1. The microemulsion was optimized using mixture optimal design. The optimized formulation was
evaluated for various evaluation parameters. The optimized microemulsion was incorporated in the gel base to obtain
final dosage form. The drug release study of the final gel was performed ex-vivo using Franz diffusion cell using rat skin
as a transdermal barrier.
|
| Keyword:
|
Atomoxetine Hydrochloride, Attention Deficit Hyperactivity Disorder, Transdermal, Microemulsion based gel
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2019.11.03.021
|
| Download:
|
Request For Article
|
|
|