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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of Silymarin on DOCA salt Streptozotocin induced diabetic hypertension in unilateral nephrectomized rats.

Author: UPLOADED BY-ADMIN, G. B. JADHAV, C. D. UPASANI
Abstract: The objective of the present investigation was to evaluate the therapeutic efficacy of Silymarin in DOCA salt Streptozotocin induced diabetic hypertension in unilateral nephrectomized rats.Unilateral nephrectomy was performed in female Wistar rats (150-200 g). A week after unilateral nephrectomy, diabetic hypertension was produced by administration of single dose of Streptozotocin (60 mg/kg, i. p.) and Deoxycorticosterone acetate (DOCA) (25mg/kg, once a week; s.c; for 4 weeks) dispersed in cottonseed oil. The effect of Silymarin (300 mg/kg and 500 mg/kg, p. o., for 4 weeks) was evaluated in DOCA salt streptozotocin induced diabetic hypertension in unilateral nephrectomized rats. Systolic blood pressure (BP), blood glucose level and lipid profile was measured once every week during the treatment schedule. After completion of treatment schedule, heart rate, arterial blood pressure and vascular reactivity to various drugs were recorded. Rats from individual group were sacrificed, the heart was dissected out and antioxidant enzyme level SOD, CAT, GSH and TBARS were measured. Urinary Na+and K+ excretions were measured by flame photometer. The isolated heart of rat from each group was also subjected to histopathology study.Silymarin (300, 500 mg/kg/day, p.o.) significantly (p<0.05) reduced systolic blood pressure, blood glucose level, heart rate, basal arterial blood pressure and pressor responses to NA, Adr, PE and 5-HT in animals treated with DOCA salt streptozotocin as compared with diabetic hypertensive rats. Silymarin significantly increased antioxidant enzyme level of SOD, CAT, GSH, urinary K+ excretion and decreased GSH level, urinary Na+ excretion compared with diabetic hypertensive group. Silymarin exhibits significant antihypertensive and antidiabetic activity in DOCA salt Streptozotocin combine model of diabetic hypertension.
Keyword: Hypertension; Diabetes; Silymarin; DOCA; Streptozotocin; Antioxidant.
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